Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg.
Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg.
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大麻素增强作用的临床前研究。
DOI：
10.1007/s00213-016-4244-7
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发表时间：
2016
影响因子：
3.4
通讯作者：
Tanda,Gianluigi
中科院分区：
文献类型：
--
作者：
Tanda,Gianluigi
大多数滥用药物的强化作用一直在动物模型中得到证实和研究，尽管大麻的强化作用并没有得到证实，直到15年前证明δ-9-四氢大麻酚（THC）可以在松鼠猴的自我给药（SA）程序中起作用。在此之前，这些影响是推断使用间接assessment.ObjectivesThe的目的，这份手稿是审查的主要临床前程序，用于间接和直接推断cannabinoid drugs.MethodsResults增强效果将审查从研究大麻素歧视，颅内自我刺激（ICSS），条件性位置偏爱（CPP），以及在与强化相关的大脑区域中评估的多巴胺水平的变化，最后来自自我给药程序。对于每一个程序，将作出评估的预测有效性在检测潜在的滥用倾向的大麻素的基础上开创性的论文，从最近几年，特别是那些从戈德堡博士的研究group.Results和conclusionsICSS和CPP的选择报告的增加不提供一致的结果，为评估潜在的滥用大麻素。然而，药物识别和神经化学程序似乎可以检测到滥用大麻素的可能性，以及几种新型的“设计师大麻素药物”。虽然在15年后，大麻滥用的自我管理模式从松鼠猴转移到其他物种仍然存在一些问题，但对前一物种的研究已经大大推进了该领域，并且已经发表了几份关于啮齿动物大麻素激动剂自我管理的报告。
RationaleThe reinforcing effects of most abused drugs have been consistently demonstrated and studied in animal models, although those of marijuana were not, until the demonstration 15 years ago that delta-9-tetrahydrocannabinol (THC) could serve as a reinforcer in self-administration (SA) procedures in squirrel monkeys. Until then, those effects were inferred using indirect assessments.ObjectivesThe aim of this manuscript is to review the primary preclinical procedures used to indirectly and directly infer reinforcing effects of cannabinoid drugs.MethodsResults will be reviewed from studies of cannabinoid discrimination, intracranial self-stimulation (ICSS), conditioned place preference (CPP), as well as change in levels of dopamine assessed in brain areas related to reinforcement, and finally from self-administration procedures. For each procedure, an evaluation will be made of the predictive validity in detecting the potential abuse liability of cannabinoids based on seminal papers, with the addition of selected reports from more recent years especially those from Dr. Goldberg’s research group.Results and conclusionsICSS and CPP do not provide consistent results for the assessment of potential for abuse of cannabinoids. However, drug discrimination and neurochemistry procedures appear to detect potential for abuse of cannabinoids, as well as several novel “designer cannabinoid drugs.” Though after 15 years transfer of the self-administration model of marijuana abuse from squirrel monkeys to other species remains somewhat problematic, studies with the former species have substantially advanced the field, and several reports have been published with consistent self-administration of cannabinoid agonists in rodents.