Primary synovial sarcoma of the lung
Primary synovial sarcoma of the lung
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DOI：
10.2169/internalmedicine.45.1508
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发表时间：
2006-01-01
影响因子：
1.2
通讯作者：
Forteza, Jeronimo
中科院分区：
文献类型：
--
作者：
Zamarron, Carlos;Abdulkader, Ihab;Forteza, Jeronimo
一位45岁女性在胸片上表现为胸痛和一个明确的椭圆形肿块。怀疑为恶性肺肿瘤，行右侧全肺切除术。肿瘤大小约13 × 12厘米，颜色淡黄色，质地柔软。组织学上，细胞圆形至卵圆形，梭形，胞质少，核深染，有丝分裂不明显，仅有少量纤维间质。免疫组化结果显示，肿瘤细胞vimentin、cd99、BCL-2蛋白、EMA均呈阳性。逆转录聚合酶链反应（RT-PCR），使用从新鲜冷冻组织中提取的RNA，证实SYT/SSX-2融合转录物，确认滑膜肉瘤的诊断。
A 45-year-old woman presented chest pain and a well-defined oval shaped mass on a chest radiograph. A malignant pulmonary tumor was suspected and a right pneumonectomy was performed. The tumor measured about 13 x 12 cm, was pale-yellow in color and soft in texture. Histologically, it had round to oval and spindle-shaped cells with minimal cytoplasm, hyperchromatic nuclei, inconspicuous mitoses and only slight fibrous stroma. Immunohistochemically, the tumor cells were positive for vimentin, CD 99, BCL-2 protein and EMA. The reverse transcriptase-polymerase chain reaction (RT-PCR), using RNA extracted from fresh-frozen tissue, demonstrated SYT/SSX-2 fusion transcripts, confirming the diagnosis of synovial sarcoma.