Early Regulation of Axolotl Limb Regeneration
Early Regulation of Axolotl Limb Regeneration
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DOI：
10.1002/ar.22529
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发表时间：
2012-10-01
影响因子：
2
通讯作者：
Satoh, Akira
中科院分区：
文献类型：
--
作者：
Makanae, Aki;Satoh, Akira
两栖动物肢体再生的研究已经有很长的时间了。在两栖动物的肢体再生中，在截肢损伤的区域周围形成未分化的芽基。芽基形成的诱导过程在很大程度上仍然是未知的，因为它是难以研究的诱导肢体再生。最近开发的副肢模型（ALM）允许调查的肢体诱导，并揭示了两栖动物肢体再生的早期事件。神经和伤口表皮/上皮之间的相互作用是肢体再生的重要方面。在早期肢体再生期间，神经营养因子作用于伤口上皮，导致称为顶端上皮帽（AEC）的功能性表皮/上皮的发育。AEC和神经创造了一个特定的环境，抑制伤口愈合，并通过芽基形成诱导再生。这表明FGF信号传导和MMP活动参与创造再生环境。为了理解为什么有尾目两栖动物可以创造这样一个再生环境，而人类不能，有必要确定再生和非再生动物之间的相似性和差异。在这里，我们专注于ALM考虑肢体再生从一个新的角度来看，我们还报道了粘着斑激酶（FAK）Src信号控制成纤维细胞迁移的蝾螈肢体再生。Anat Rec，2012. (c)2012 Wiley Periodicals，Inc.
Amphibian limb regeneration has been studied for a long time. In amphibian limb regeneration, an undifferentiated blastema is formed around the region damaged by amputation. The induction process of blastema formation has remained largely unknown because it is difficult to study the induction of limb regeneration. The recently developed accessory limb model (ALM) allows the investigation of limb induction and reveals early events of amphibian limb regeneration. The interaction between nerves and wound epidermis/epithelium is an important aspect of limb regeneration. During early limb regeneration, neurotrophic factors act on wound epithelium, leading to development of a functional epidermis/epithelium called the apical epithelial cap (AEC). AEC and nerves create a specific environment that inhibits wound healing and induces regeneration through blastema formation. It is suggested that FGF-signaling and MMP activities participate in creating a regenerative environment. To understand why urodele amphibians can create such a regenerative environment and humans cannot, it is necessary to identify the similarities and differences between regenerative and nonregenerative animals. Here we focus on ALM to consider limb regeneration from a new perspective and we also reported that focal adhesion kinase (FAK)Src signaling controlled fibroblasts migration in axolotl limb regeneration. Anat Rec, 2012. (c) 2012 Wiley Periodicals, Inc.