Effects of systemic cholinergic antagonism on reinforcer devaluation in macaques.
Effects of systemic cholinergic antagonism on reinforcer devaluation in macaques.
复制标题
全身胆碱能拮抗作用对猕猴强化物贬值的影响。
DOI：
10.1016/j.neulet.2018.05.003
复制
发表时间：
2018
影响因子：
2.5
通讯作者：
Turchi,Janita
中科院分区：
文献类型：
--
作者：
Waguespack,HannahF;Málková,Ludise;Forcelli,PatrickA;Turchi,Janita
根据新信息调整行为的能力是一项至关重要的认知功能。动物根据奖励值的变化适应行为反应的能力可以通过强化物贬值任务来衡量，其中通过减少相关食物强化的价值来降低给定物体的可取性。在啮齿类动物和非人类灵长类动物中，已经研究了服务于这种能力的神经回路的元素。具体来说，杏仁核基底外侧、眶额皮质、伏隔核和丘脑中背侧都被证明在价值更新过程中发挥关键作用，这是适应性目标选择所必需的。由于这些区域接受密集的胆碱能输入，我们研究了系统注射非选择性烟碱或毒菌碱乙酰胆碱受体拮抗剂，分别是甲胺和东莨菪碱，是否会损害强化剂贬值任务的表现。在这里，我们证明了在烟碱或毒蕈碱拮抗剂存在的情况下，动物能够以适当的方式改变它们的行为反应，这表明在恒河猴中，胆碱能神经调节的破坏不足以破坏价值更新和随后的目标选择。
The capacity to adjust actions based on new information is a vital cognitive function. An animal’s ability to adapt behavioral responses according to changes in reward value can be measured using a reinforcer devaluation task, wherein the desirability of a given object is reduced by decreasing the value of the associated food reinforcement. Elements of the neural circuits serving this ability have been studied in both rodents and nonhuman primates. Specifically, the basolateral amygdala, orbitofrontal cortex, nucleus accumbens, and mediodorsal thalamus have each been shown to play a critical role in the process of value updating, required for adaptive goal selection. As these regions receive dense cholinergic input, we investigated whether systemic injections of non-selective nicotinic or muscarinic acetylcholine receptor antagonists, mecamylamine and scopolamine, respectively, would impair performance on a reinforcer devaluation task. Here we demonstrate that in the presence of either a nicotinic or muscarinic antagonist, animals are able to shift their behavioral responses in an appropriate manner, suggesting that disruption of cholinergic neuromodulation is not sufficient to disrupt value updating, and subsequent goal selection, in rhesus macaques.