Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits
Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits
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DOI：
10.1161/hh2301.099646
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发表时间：
2001-11-23
影响因子：
20.1
通讯作者：
Napoli, C
中科院分区：
文献类型：
--
作者：
Palinski, W;D'Armiento, FP;Napoli, C
妊娠期母体高胆固醇血症与胎儿脂肪条纹形成增强和儿童期动脉粥样硬化进展加快相关，即使在正常胆固醇血症条件下。先前已在家兔中确定了母体高胆固醇血症在胎儿发育过程中病变形成中的因果作用。同样的实验模型现在被用于确定母体高胆固醇血症或随后的胎儿动脉致病事件增强了以后的动脉粥样硬化形成。五组兔母亲在怀孕期间喂食食物、富含胆固醇的食物或富含胆固醇的食物加1000 IU维生素E、3%消胆胺或两者。所有组的后代（n = 136）被喂食轻度高胆固醇血症饮食长达一年，并且具有相似的胆固醇水平。在出生、6个月或12个月时测定血浆中主动脉病变大小和脂质过氧化产物以及后代病变。高胆固醇血症母亲的后代的病变进展大于所有其他组。在每个时间点，高胆固醇血症母亲的后代比正常胆固醇血症母亲的后代有1.5- 3倍大的病变（P
Maternal hypercholesterolemia during pregnancy is associated with enhanced fatty streak formation in human fetuses and faster progression of atherosclerosis during childhood even under normocholesterolemic conditions. A causal role of maternal hypercholesterolemia in lesion formation during fetal development has previously been established in rabbits. The same experimental model is now used to establish that maternal hypercholesterolemia or ensuing pathogenic events in fetal arteries enhance atherogenesis later in life. Five groups of rabbit mothers were fed chow, cholesterol-enriched chow, or cholesterol-enriched chow plus 1000 lU vitamin E, 3% cholestyramine, or both during pregnancy. Offspring of all groups (n = 136) were fed a mildly hypercholesterolemic diet for up to a year and had similar cholesterol levels. Aortic lesion sizes and lipid peroxidation products in plasma and lesions in offspring were determined at birth, 6 months, or 12 months. Lesion progression in offspring of hypercholesterolemic mothers was greater than in all other groups. At each time point, offspring of hypercholesterolemic mothers had 1.5- to 3-fold larger lesions than offspring of normocholesterolemic mothers (P