Structural brain differences do not mediate the relations between sex and personality or psychopathology.
Structural brain differences do not mediate the relations between sex and personality or psychopathology.
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大脑结构差异并不调节性别与人格或精神病理学之间的关系。
DOI：
10.1111/jopy.12704
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发表时间：
2022
影响因子：
5
通讯作者：
Miller,JoshuaD
中科院分区：
文献类型：
--
作者：
Hyatt,CourtlandS;Listyg,BenjaminS;Owens,MaxM;Carter,NathanT;Carter,DorothyR;Lynam,DonaldR;Harden,KPaige;Miller,JoshuaD
简介男性和女性在人格特征和精神病理学指标方面往往表现出微小但可靠的差异，这些差异随着时间的推移和跨文化而相对稳定。先前的研究表明，大脑结构中的性别差异可以解释认知领域的差异。方法我们使用人类连接组计划（N = 1098）的数据来测试大脑形态测量中的性别差异是否可以解释所观察到的人格特质神经质和宜人性以及内化和外化精神病理学症状的差异。我们以三种方式操作大脑形态测量：综合测量（例如，总灰质体积）、通过多模态分割方法定义的格拉瑟区域以及由大脑结构特征定义的Desikan区域。结果观察到了人格、精神病理学和大脑形态测量中最预期的性别差异，但统计中介分析无效：大脑形态测量中的性别差异并不能解释人格或精神病理学中的性别差异。结论男性和女性往往在人格上表现出有意义的差异和精神病理学，以及格拉瑟和德西坎地图集定义的综合形态测量和区域形态测量差异，但这些形态测量差异似乎与心理差异无关。
IntroductionMales and females tend to exhibit small but reliable differences in personality traits and indices of psychopathology that are relatively stable over time and across cultures. Previous work suggests that sex differences in brain structure account for differences in domains of cognition.MethodsWe used data from the Human Connectome Project (N= 1098) to test whether sex differences in brain morphometry account for observed differences in the personality traits neuroticism and agreeableness, as well as symptoms of internalizing and externalizing psychopathology. We operationalized brain morphometry in three ways: omnibus measures (e.g., total gray matter volume), Glasser regions defined through a multi‐modal parcellation approach, and Desikan regions defined by structural features of the brain.ResultsMost expected sex differences in personality, psychopathology, and brain morphometry were observed, but the statistical mediation analyses were null: sex differences in brain morphometry did not account for sex differences in personality or psychopathology.ConclusionsMen and women tend to exhibit meaningful differences in personality and psychopathology, as well as in omnibus morphometry and regional morphometric differences as defined by the Glasser and Desikan atlases, but these morphometric differences appear unrelated to the psychological differences.