RISK OF PANCREATIC-CANCER IN RELATION TO MEDICAL HISTORY AND THE USE OF TOBACCO, ALCOHOL AND COFFEE
RISK OF PANCREATIC-CANCER IN RELATION TO MEDICAL HISTORY AND THE USE OF TOBACCO, ALCOHOL AND COFFEE
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DOI：
10.1002/ijc.2910450504
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发表时间：
1990-05-15
影响因子：
6.4
通讯作者：
DAVIS, S
中科院分区：
文献类型：
--
作者：
FARROW, DC;DAVIS, S
进行了一项基于人群的病例对照研究，以检查某些医疗状况、烟草、酒精和咖啡的使用与胰腺癌发病率之间的关系。病例 (N = 148) 是 1982 年 7 月至 1986 年 6 月期间被诊断患有胰腺癌、年龄在 20 岁至 74 岁之间的已婚男性。对照 (N = 188) 通过随机数字拨号来识别。妻子作为病例和对照的代理人，接受了电话采访，并单独完成了一份食物频率调查问卷。有糖尿病或胰腺炎病史的个体患胰腺癌的风险增加，而有扁桃体切除史的个体患胰腺癌的风险降低。曾经吸烟的人患病的风险较高。这种超额风险仅限于当前吸烟者，其比值比为 3.2 (95% Cl 1.8-5.7)；以前吸烟者的风险与从未吸烟者相似。曾经使用过其他形式烟草（包括斗烟、雪茄和咀嚼烟草）的人患胰腺癌的风险并没有过高。调整人口和饮食特征后，胰腺癌风险与咖啡、啤酒、红酒、烈性酒或所有酒精的摄入量之间没有关联；每天饮用白葡萄酒的人的风险略有降低。
A population-based case-control study was conducted to examine the relationship between certain medical conditions, the use of tobacco, alcohol and coffee, and the incidence of pancreatic cancer. Cases (N = 148) were married men ages 20 through 74 years diagnosed with pancreatic cancer from July 1982 through June 1986. Controls (N = 188) were identified by random digit dialing. Wives, responding as surrogates for both cases and controls, were interviewed by telephone and completed, alone, a food frequency questionnaire. The risk of pancreatic cancer was increased in individuals with a history of diabetes or pancreatitis, and decreased in those with a history of tonsillectomy. Individuals who had ever smoked cigarettes were at elevated risk of disease. This excess risk was confined to current smokers, in whom the odds ratio was 3.2 (95% Cl 1.8-5.7); the risk among former smokers resembled that in those who had never smoked. There was no excess risk of pancreatic cancer among those who had ever used other forms of tobacco, including pipe tobacco, cigars and chewing tobacco. After adjustment for demographic and dietary characteristics, there was no association between pancreatic cancer risk and the intake of coffee, beer, red wine, hard liquor or all alcohol combined; a slight reduction in risk was seen among those consuming white wine daily.