Clinical burden of preoperative albumin-globulin ratio in esophageal cancer patients
Clinical burden of preoperative albumin-globulin ratio in esophageal cancer patients
复制标题
DOI：
10.1016/j.amjsurg.2017.04.007
复制
发表时间：
2017-11-01
影响因子：
3
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
--
作者：
Oki, Satoshi;Toiyama, Yuji;Kusunoki, Masato
背景：在一些癌症中，较低的白蛋白-球蛋白比率（AGR）与死亡率增加有关。然而，尚无研究评估食管癌（EC）患者的AGR与预后之间的关系。方法：对112例行手术的EC患者的临床病理表现及术前实验室资料（癌胚抗原、鳞状细胞癌抗原、总蛋白、白蛋白）进行评估，以确定早期复发和预后不良的指标。AGR计算为白蛋白/（总蛋白-白蛋白）。结果：较低的AGR与肿瘤进展显著相关。CEA水平是总生存期（OS）和无病生存期（DFS）的独立预测因子。AGR和CEA联合检测被认为是预后不良和早期复发的可行指标。在无淋巴结转移的EC患者中，AGR低的患者的DFS和OS较AGR高的患者差。结论：AGR是EC患者OS和DFS的重要预测因子。在没有淋巴结转移的EC患者中，AGR可能有助于确定可能从更强化的辅助治疗中获益的候选人。(c) 2017 Elsevier Inc.版权所有。
Background: Lower albumin-globulin ratio (AGR) is associated with increased mortality in several cancers. However, no studies have evaluated the relationship between the AGR and prognostic outcome in esophageal cancer (EC) patients.Methods: To identify indicators of early recurrence and poor prognosis, we assessed the clinicopathological findings and preoperative laboratory data (carcinoembryonic antigen [CEA], squamous cell carcinoma antigen, total protein, and albumin) of 112 EC patients who underwent surgery. The AGR was calculated as albumin/(total protein-albumin).Results: A lower AGR was significantly associated with tumor progression. The CEA level was an independent predictor for overall survival (OS) and disease-free survival (DFS). The AGR and CEA combination was identified as a feasible indicator of poor prognosis and early recurrence. Among EC patients without lymph node metastasis, those with lower AGR had poorer DFS and OS than those with higher AGR.Conclusion: AGR was identified as a significant predictor of OS and DFS in EC patients. Among EC patients without lymph node metastasis, AGR may help identify candidates who might benefit from more intensive adjuvant therapy. (c) 2017 Elsevier Inc. All rights reserved.