Choroid plexus tumours.
Choroid plexus tumours.
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DOI：
10.1038/sj.bjc.6600609
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发表时间：
2002-11-04
影响因子：
8.8
通讯作者：
Egeler, RM
中科院分区：
文献类型：
--
作者：
Wolff, JEA;Sajedi, M;Brant, R;Coppes, MJ;Egeler, RM
脉络膜丛肿瘤是一种罕见的上皮性脑肿瘤，关于其生物学和最佳治疗方法的信息有限。进行了荟萃分析，以确定预后因素和各种治疗方式的影响。对医学文献（1966-1998）的全面回顾揭示了566例记录良好的脉络膜丛肿瘤。这些数据被输入数据库，并进行分析，以确定预后因素和治疗方式。幕上肿瘤的大多数患者是儿童，而成人最常见的部位是第四脑室和小脑脑桥角。小脑脑桥角肿瘤多为良性。组织学是最重要的预后因素，脉络膜丛-乳头状瘤（n=353）的1年、5年和10年预计生存率分别为90%、81%和77%，而脉络膜丛-癌的预测生存率分别为71%、41%和35% （P<0.0005）。手术对脉络膜丛-乳头状瘤（P=0.0005）和脉络膜丛-癌（P=0.0001）的预后均有影响。放疗与脉络膜丛癌的生存率显著提高相关。22例脉络膜丛癌中有8例对化疗有反应。初次治疗后复发是脉络膜丛癌患者预后不良的因素，而不是脉络膜丛乳头状瘤患者。脉络膜丛肿瘤的治疗应从根治性手术切除开始。如果是脉络膜丛癌，则应进行辅助治疗，如果是脉络膜丛乳头状瘤，则应采取“观望”方法。英国癌症杂志（2002）87,1086-1091。doi: 10.1038 / sj.bjc。6600609 www.bjcancer.com©2002英国癌症研究中心
Choroid plexus tumours are rare epithelial brain tumours and limited information is available regarding their biology and the best treatment. A meta-analysis was done to determine prognostic factors and the influence of various treatment modalities. A thorough review of the medical literature (1966–1998) revealed 566 well-documented choroid plexus tumours. These were entered into a database, which was analysed to determine prognostic factors and treatment modalities. Most patients with a supratentorial tumour were children, while the most common sites in adults were the fourth ventricle and the cerebellar pontine angle. Cerebellar pontine angle tumours were more frequently benign. Histology was the most important prognostic factor, as one, five, and 10-year projected survival rates were 90, 81, and 77% in choroid plexus-papilloma (n=353) compared to only 71, 41, and 35% in choroid plexus-carcinoma respectively (P<0.0005). Surgery was prognostically relevant for both choroid plexus-papilloma (P=0.0005) and choroid plexus-carcinoma (P=0.0001). Radiotherapy was associated with significantly better survival in choroid plexus-carcinomas. Eight of 22 documented choroid plexus-carcinomas responded to chemotherapy. Relapse after primary treatment was a poor prognostic factor in choroid plexus-carcinoma patients but not in choroid plexus-papilloma patients. Treatment of choroid plexus tumours should start with radical surgical resection. This should be followed by adjuvant treatment in case of choroid plexus-carcinoma, and a ‘wait and see’ approach in choroid plexus-papilloma. British Journal of Cancer (2002) 87, 1086–1091. doi:10.1038/sj.bjc.6600609 www.bjcancer.com © 2002 Cancer Research UK
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影响因子：
1.9
作者：
Hashizume, Akira;Kodama, Yasunori;Hada, Yoshihiro
通讯作者：
Hada, Yoshihiro
影响因子：
4.8
作者：
KIMURA, M;TAKAYASU, M;SCHEITHAUER, BW
通讯作者：
SCHEITHAUER, BW
影响因子：
1.4
作者：
Costa, JM;Ley, L;Lafuente, J
通讯作者：
Lafuente, J
DOI：
10.1159/000120378
发表时间：
1988-01-01
期刊：
PEDIATRIC NEUROSCIENCE
影响因子：
--
作者：
GRIFFIN, BR;STEWART, GR;ODELL, M
通讯作者：
ODELL, M
影响因子：
1.7
作者：
HAMANO, K;MATSUBARA, T;TAKITA, H
通讯作者：
TAKITA, H