Effect of maternal iron deficiency anemia on fetal neural development
Effect of maternal iron deficiency anemia on fetal neural development
复制标题
DOI：
10.1038/s41372-017-0023-5
复制
发表时间：
2018-03-01
影响因子：
2.9
通讯作者：
Kumar, Ashok
中科院分区：
文献类型：
--
作者：
Basu, Sriparna;Kumar, Dinesh;Kumar, Ashok
目的：围产期缺铁可能对胎儿神经发育造成不良后果。为探讨母亲缺铁性贫血对胎儿海马区形态发生和脑源性神经营养因子产生的影响。研究设计：以母亲缺铁性贫血(血红蛋白=110g/L，血清铁蛋白和谷草转铁蛋白12mg/L)所生的单胎新生儿为对照。排除母婴炎症、感染和围产期窒息新生儿。采用酶联免疫吸附试验测定脐血BDNF浓度。结果：研究组中轻度24例(血红蛋白100.0~109.0 g/L)，中度24例(血红蛋白70.0~99.0g/L)，重度22例(血红蛋白70.0~99.0g/L)
Objective: Perinatal iron deficiency may have deleterious consequences on fetal neural development. The present study was conducted to determine the effect of maternal iron deficiency anemia (IDA) on fetal hippocampal morphogenesis and production of brain-derived neurotrophic factor (BDNF).Study design: Seventy term, singleton neonates born to mothers with IDA (hemoglobin = 110 g/L and serum ferritin >12 mu g/L) served as controls. Maternal and fetal inflammatory conditions, infections and neonates with perinatal asphyxia were excluded. Cord blood BDNF concentrations were estimated by enzyme-linked immunosorbent assay. Volumetric analysis of hippocampus (right, left and combined, corrected for total intracranial volume) was done by cranial magnetic resonance imaging on days 3-5 of life.Results: In the study group, 24 mothers had mild (hemoglobin 100.0-109.0 g/L), 24 had moderate (hemoglobin 70.0-99.0 g/L), and 22 had severe (hemoglobin