Hyperprolactinaemia attenuates the gonadotrophin releasing hormone receptor response to gonadectomy in rats.
Hyperprolactinaemia attenuates the gonadotrophin releasing hormone receptor response to gonadectomy in rats.
复制标题
高催乳素血症会减弱大鼠促性腺激素释放激素受体对性腺切除术的反应。
DOI：
10.1677/joe.0.0950267
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
L. C. Bailey
中科院分区：
文献类型：
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作者：
R. Clayton;L. C. Bailey
垂体促性腺激素释放激素 (Gn-RH) 受体含量的测量提供了垂体先前暴露于内源性 Gn-RH 的定性指标。研究了肾囊下三个垂体移植物造成的中度高催乳素血症（血清催乳素 = 95-250 微克/1）对成年大鼠性腺切除术后垂体 Gn-RH 受体含量和血清 LH 反应的影响。在男性中，高泌乳素血症持续7天，完全阻止了去势后3天Gn-RH受体含量的增加，并抑制了血清LH的升高45%。去势后 6 天，高催乳素血症去势动物的 Gn-RH 受体增加，但值比假移植对照低 33%，而血清 LH 增加减弱 30%。去势后 6 天的移植去势动物的垂体 LH 含量也较低。高泌乳素血症持续3周对完整雄性大鼠的Gn-RH受体或垂体LH含量没有影响，尽管基础血清LH降低了50%。高泌乳素血症还减弱了雌性大鼠卵巢切除术后 6 天发生的 Gn-RH 受体、血清 LH 和垂体 LH 的增加。在所有实验中，移植垂体的动物的垂体催乳素含量减少了 80-90%。这些结果表明，高催乳素血症通过减少内源性下丘脑 Gn-RH 分泌来限制 Gn-RH 受体对性腺切除术的反应。
Measurement of pituitary gonadotrophin releasing hormone (Gn-RH) receptor content provides a qualitative index of prior exposure of the pituitary gland to endogenous Gn-RH. The effect of moderate hyperprolactinaemia (serum prolactin = 95-250 micrograms/1), achieved with three pituitary grafts beneath the renal capsule, on the pituitary Gn-RH receptor content and serum LH responses to gonadectomy of adult rats has been studied. In males the presence of hyperprolactinaemia for 7 days completely prevented the increase in Gn-RH receptor content 3 days after castration and inhibited the serum LH rise by 45%. By 6 days after castration, Gn-RH receptors had increased in the hyperprolactinaemic castrated animals but values were 33% lower than in sham-grafted controls, while the serum LH increase attenuated by 30%. Pituitary LH content was also lower in grafted castrated animals 6 days after castration. Hyperprolactinaemia for 3 weeks had no effect on Gn-RH receptors or pituitary LH content of intact male rats, although basal serum LH was decreased by 50%. Hyperprolactinaemia also attenuated the increases in Gn-RH receptors, serum LH and pituitary LH which occurred 6 days after ovariectomy in female rats. In all experiments the pituitary content of prolactin was reduced by 80-90% in animals bearing pituitary grafts. These results suggest that hyperprolactinaemia restricts the Gn-RH receptor response to gonadectomy by decreasing endogenous hypothalamic Gn-RH secretion.