Ultrathin Cell-Membrane-Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for InVivo Electrochemical Detection
Ultrathin Cell-Membrane-Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for InVivo Electrochemical Detection
复制标题
超薄细胞膜模拟磷酸胆碱聚合物薄膜涂层可大幅改进体内电化学检测
DOI：
10.1002/anie.201705900
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发表时间：
2017-09-18
影响因子：
16.6
通讯作者：
Mao, Lanqun
中科院分区：
文献类型：
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作者：
Liu, Xiaomeng;Xiao, Tongfang;Mao, Lanqun
抑制生物分子在脑植入微电极表面的吸附是神经化学物质体内监测的关键问题。在这里，我们证明了在碳纤维微电极(CFE)表面上电聚合的乙二氧基噻吩膜(EDOT-PC)不仅能抵抗蛋白质的吸附，还能保持体内监测多巴胺(DA)的灵敏度和时间响应。因此，所制备的PEDOT-PC/CFES可作为体内示踪DA的新的可靠平台，并有助于了解DA的生理和病理功能。
Resisting biomolecule adsorption onto the surface of brain-implanted microelectrodes is a key issue for invivo monitoring of neurochemicals. Herein, we demonstrate that an ultrathin cell-membrane-mimic film of ethylenedioxythiophene tailored with zwitterionic phosphorylcholine (EDOT-PC) electropolymerized onto the surface of a carbon fiber microelectrode (CFE) not only resists protein adsorption but also maintains the sensitivity and time response for invivo monitoring of dopamine (DA). As a consequence, the as-prepared PEDOT-PC/CFEs could be used as a new reliable platform for tracking DA invivo and would help understand the physiological and pathological functions of DA.