Arachidonate is an antagonist of platelet activation by the endoperoxide analog U46619.
Arachidonate is an antagonist of platelet activation by the endoperoxide analog U46619.
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花生四烯酸是内过氧化物类似物 U46619 的血小板活化拮抗剂。
DOI：
10.1016/0304-4165(82)90365-8
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Detwiler,TC
中科院分区：
文献类型：
--
作者：
Huang,EM;Detwiler,TC
在存在环氧合酶抑制剂的情况下，花生四烯酸通过内过氧化物类似物U46619抑制血小板活化。抑制程度取决于U46619和花生四烯酸的浓度。该机制显然不涉及花生四烯酸代谢，因为（i）预孵育不增强抑制作用，（ii）抑制脂氧合酶不阻止抑制作用，（iii）二十碳四炔酸和二高-γ-亚麻酸也具有抑制作用。在相似的条件下，其他激动剂对血小板的激活作用仅受到轻微抑制。
In the presence of cyclooxygenase inhibitors, arachidonate inhibits platelet activation by the endoperoxide analog U46619. The degree of inhibition depends on the concentrations of U46619 and arachidonate. The mechanism apparently does not involve arachidonate metabolism, because (i) pre-incubation did not enhance inhibition, (ii) inhibition of lipoxygenase did not prevent inhibition, and (iii) eicosatetraynoate and dihomo-γ-linolenate were also inhibitory. Under similar conditions, activation of platelets by other agonists was only slightly inhibited.