Altered White Matter Connectivity Associated with Intergyral Brain Disorganization in Hemiplegic Cerebral Palsy
Altered White Matter Connectivity Associated with Intergyral Brain Disorganization in Hemiplegic Cerebral Palsy
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DOI：
10.1016/j.neuroscience.2018.12.028
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发表时间：
2019-02-10
期刊：
影响因子：
3.3
通讯作者：
Im, Kiho
中科院分区：
文献类型：
--
作者：
Papadelis, Christos;Ahtam, Banu;Im, Kiho
尽管大量文献显示偏瘫型脑瘫（HCP）儿童的感觉运动投射纤维受损，但对这些损伤如何影响全球脑网络知之甚少。在这项研究中，我们评估了HCP儿童感觉运动投射纤维结构完整性与脑回间联合白色物质连接完整性之间的关系。对10例HCP患儿和16例发育正常儿童进行了扩散张量成像。我们使用基于感兴趣区域（ROI）的方法和基于全脑回的包裹方法估计了区域和全局白质连接。使用基于ROI的方法，我们追踪了脊髓丘脑（STh）、丘脑皮质（ThC）、皮质脊髓（CST）和感觉运动U-（SMU）纤维。使用全脑包裹的方法，我们跟踪了短，中，长距离的关联纤维。我们观察到，对于患有HCP的儿童的更受影响的半球：（i）STh和ThC纤维的轴向扩散率（AD）、平均扩散率（MD）和径向扩散率（RD）增加;（ii）CST和SMU纤维的各向异性分数（FA）减少，MD和RD增加;在（iii）减少FA和增加AD，MD和RD的中，长距离的关联纤维;和（iv）之间的关联完整性的感觉运动投射和脑回间的关联纤维。我们的研究结果表明，改变结构的完整性的感觉运动投射纤维瓦解的intergyral协会白色物质之间的连接与HCP儿童的本地和远程地区。(C)2018年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Despite extensive literature showing damages in the sensorimotor projection fibers of children with hemiplegic cerebral palsy (HCP), little is known about how these damages affect the global brain network. In this study, we assess the relationship between the structural integrity of sensorimotor projection fibers and the integrity of intergyral association white matter connections in children with HCP. Diffusion tensor imaging was performed in 10 children with HCP and 16 typically developing children. We estimated the regional and global white-matter connectivity using a region-of-interest (ROI)-based approach and a whole-brain gyrus-based parcellation method. Using the ROI-based approach, we tracked the spinothalamic (STh), thalamocortical (ThC), corticospinal (CST), and sensorimotor U- (SMU) fibers. Using the whole-brain parcellation method, we tracked the short-, middle-, and long-range association fibers. We observed for the more affected hemisphere of children with HCP: (i) an increase in axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) for the STh and ThC fibers; (ii) a decrease in fractional anisotropy (FA) and an increase in MD and RD for the CST and SMU fibers; in (iii) a decrease in FA and an increase in AD, MD, and RD for the middle- and long-range association fibers; and (iv) an association between the integrity of sensorimotor projection and intergyral association fibers. Our findings indicate that altered structural integrity of the sensorimotor projection fibers disorganizes the intergyral association white matter connections among local and distant regions in children with HCP. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.