Fibromyalgia in the irritable bowel syndrome: Studies of prevalence and clinical implications
Fibromyalgia in the irritable bowel syndrome: Studies of prevalence and clinical implications
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DOI：
10.1111/j.1572-0241.1999.01643.x
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发表时间：
1999-12-01
影响因子：
9.8
通讯作者：
Buskila, D
中科院分区：
文献类型：
--
作者：
Sperber, AD;Atzmon, Y;Buskila, D
目的：肠易激综合征（IBS）和纤维肌痛综合征（FS）在许多患者中共存。我们进行了补充研究的患病率FS在IBS患者和匹配的对照组，和IBS的FS患者和伴随的IBS和FS对健康相关的生活质量（HRQOL）的影响：一项研究79 IBS患者与72匹配的对照组（IBS研究），和一项研究100 FS患者（FS研究）。所有参与者进行了压痛点部位和压痛阈值的测试，并回答了问卷调查，包括个人和病史，GI症状，HRQOL.RESULTS指数：在IBS研究中，25 79 IBS患者（31.6%）和3 72对照组（4.2%）有FS（P < 0.001）。在总体幸福感方面，研究组之间存在统计学显著差异（p < 0.001），睡眠障碍（p < 0.001），医生就诊（p = 0.003）、疼痛（p < 0.001）、焦虑（p < 0.001）和总体严重程度指数（SCL-90-R）（p < 0.001），IBS和FS患者的结果最差。IBS患者的压痛点明显多于对照组（p < 0.001）。在FS研究中，100例FS患者中有32例（32%）患有IBS。这两种疾病的患者有显着更差的评分为身体功能（p = 0.030）和所有，但一个16项的生活质量questionnaire.CONCLUSIONS：FS和IBS共存于许多患者。两种疾病患者的HRQOL指数评分均低于单独疾病患者或对照组。治疗这些患者的医生应该意识到重叠，这可能会影响症状的表现，医疗保健利用和治疗策略。(Am胃肠病学杂志1999;94：3541-3546. (C)1999年，我胃肠病学）。
OBJECTIVE: The irritable bowel syndrome (IBS) and the fibromyalgia syndrome (FS) coexist in many patients. We conducted complementary studies of the prevalence of FS in IBS patients and matched controls, and of IBS in FS patients and the implications of concomitant IBS and FS on health-related quality of life (HRQOL).METHODS: A study of 79 IBS patients with 72 matched controls (IBS study), and a study of 100 FS patients (FS study). All participants underwent tests of tender point sites and threshold of tenderness and answered questionnaires including personal and medical history, GI symptoms, and indices of HRQOL.RESULTS: In the IBS study, 25 of the 79 IBS patients (31.6%) and 3 of the 72 controls (4.2%) had FS (p < 0.001). Statistically significant differences were found among the study groups in terms of global well-being (p < 0.001), sleep disturbance (p < 0.001), physician visits (p = 0.003), pain (p < 0.001), anxiety (p < 0.001), and global severity index (SCL-90-R) (p < 0.001), with patients with IBS and FS having the worst results. IBS patients had significantly more tender points than controls (p < 0.001). In the FS study, 32 of the 100 FS patients (32%) had IBS. Patients with both disorders had significantly worse scores for physical functioning (p = 0.030) and for all but one of a 16-item quality of life questionnaire.CONCLUSIONS: FS and IBS coexist in many patients. Patients with both disorders have worse scores on HRQOL indices than patients with either disorder alone, or controls. Physicians treating these patients should be aware of the overlap, which can affect the presentation of symptoms, health care utilization, and treatment strategies. (Am J Gastroenterol 1999;94:3541-3546. (C) 1999 by Am. Coll. of Gastroenterology).