Putting copper into action: copper-impregnated products with potent biocidal activities
Putting copper into action: copper-impregnated products with potent biocidal activities
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DOI：
10.1096/fj.04-2029fje
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发表时间：
2004-09-01
期刊：
影响因子：
4.8
通讯作者：
Gabbay, J
中科院分区：
文献类型：
--
作者：
Borkow, G;Gabbay, J
铜离子，无论是单独的还是铜配合物，几个世纪以来一直被用来消毒液体、固体和人体组织。今天，铜被用作净水器、杀藻剂、杀真菌剂、杀线虫剂、杀软体剂、抗菌和防污剂。铜也显示出强大的抗病毒活性。我们假设将铜引入衣服、床上用品和其他物品中会提供它们的生物杀灭性能。一种耐用的平台技术已经被开发出来，该技术将铜引入棉纤维、乳胶和其他聚合物材料中。本研究证明了铜浸渍纤维和聚酯制品的广谱抗菌（抗菌、抗病毒、抗真菌）和抑菌活性。这项技术使生产抗病毒手套和过滤器（使HIV-1和其他病毒失活）、抗菌自杀菌织物（杀死耐抗生素细菌，包括耐甲氧西林金黄色葡萄球菌和耐万古霉素肠球菌）、抗真菌袜子（缓解脚气症状）和抗尘螨床垫套（减少尘螨相关过敏）成为可能。这些产品不具有皮肤致敏特性，通过豚鼠最大化和兔子皮肤刺激试验确定。我们的研究展示了铜在新应用中的潜在用途。这些应用程序处理最重要的医学问题，例如病毒传播；医院或卫生保健相关感染；以及耐抗生素细菌的传播。
Copper ions, either alone or in copper complexes, have been used for centuries to disinfect liquids, solids, and human tissue. Today copper is used as a water purifier, algaecide, fungicide, nematocide, molluscicide, and antibacterial and antifouling agent. Copper also displays potent antiviral activity. We hypothesized that introducing copper into clothing, bedding, and other articles would provide them with biocidal properties. A durable platform technology has been developed that introduces copper into cotton fibers, latex, and other polymeric materials. This study demonstrates the broad-spectrum antimicrobial ( antibacterial, antiviral, antifungal) and antimite activities of copper-impregnated fibers and polyester products. This technology enabled the production of antiviral gloves and filters (which deactivate HIV-1 and other viruses), antibacterial self-sterilizing fabrics (which kill antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci), antifungal socks (which alleviate symptoms of athlete's foot), and anti-dust mite mattress covers (which reduce mite-related allergies). These products did not have skin-sensitizing properties, as determined by guine pig maximization and rabbit skin irritation tests. Our study demonstrates the potential use of copper in new applications. These applications address medical issues of the greatest importance, such as viral transmissions; nosocomial, or healthcare-associated, infections; and the spread of antibiotic-resistant bacteria.