CYTOKINE DYSREGULATION IN CHRONIC GRAFT-VERSUS-HOST DISEASE
CYTOKINE DYSREGULATION IN CHRONIC GRAFT-VERSUS-HOST DISEASE
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DOI：
10.3109/10428199509051718
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发表时间：
1995-03-01
影响因子：
2.6
通讯作者：
NAGLER, A
中科院分区：
文献类型：
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作者：
BARAK, V;LEVISCHAFFER, F;NAGLER, A
细胞因子在慢性移植物抗宿主病（cGVHD）的发病机制中起关键作用，并且各种研究已经显示来自GVHD患者的免疫细胞异常产生细胞因子。基于这些发现和其他显示高TNF水平先于GVHD发展的发现，我们评估了BMT后和cGVHD发展期间的炎性细胞因子水平。在这项研究中，接受骨髓移植（BMT）的患者，因此发展为慢性GVHD进行了分析，他们的细胞因子的生产过程中cGVHD，这是与他们的临床表现。与对照患者或正常供体相比，发现严重程度以及主要临床并发症的数量与高水平的炎性细胞因子（IL-1 β、IL-6和TNF α）之间呈正相关。没有发生GVHD的接受BMT的患者没有产生高水平的IL-1 β、IL-6或TNF。高水平的细胞因子可用作评估新的治疗方式和对GVHD治疗的反应的工具。
Cytokines play a key role in the pathogenesis of chronic Graft versus Host Disease (cGVHD) and various studies have shown abberant production of cytokines by immune cells from GVHD patients. Based on these findings and others showing that high TNF levels precede the development of GVHD, we evaluated inflammatory cytokine levels following BMT and during the development of cGVHD. In this study, patients undergoing bone marrow transplantation (BMT) who consequently developed chronic GVHD were analyzed as to their cytokine production during cGVHD and this was correlated with their clinical manifestations. A positive correlation was found between the severity as well as the number of major clinical complications and high levels of inflammatory cytokines (IL-1 beta IL-6 and TNF alpha) compared to control patients or to normal donors. patients undergoing BMT who did not develop GVHD, did not produce high levels of IL-1 beta IL-6 or TNF. High levels of cytokines may be used as a tool for assessing novel therapeutic modalities and response to GVHD treatment.