Profiling breast cancer by array CGH
Profiling breast cancer by array CGH
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DOI：
10.1023/a:1023025506386
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发表时间：
2003-04-01
影响因子：
3.8
通讯作者：
Albertson, DG
中科院分区：
文献类型：
--
作者：
Albertson, DG
乳腺肿瘤表现出多种基因组改变。本综述重点关注这些肿瘤中的 DNA 拷贝数变化，通过最近开发的基于微阵列的比较基因组杂交形式进行测量。对这项新技术的功能进行了审查。讨论了阵列 CGH 在乳腺癌分析中的初步应用，以及可能出现特定类型拷贝数变化的机制。
Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.