Changes in gray-/white-matter ratios in the parahippocampal gyri of late-onset schizophrenia patients.
Changes in gray-/white-matter ratios in the parahippocampal gyri of late-onset schizophrenia patients.
复制标题
晚发精神分裂症患者海马旁回灰质/白质比率的变化。
DOI：
10.1176/appi.ajgp.11.6.605
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Lindzen,EricC
中科院分区：
文献类型：
--
作者：
Casanova,ManuelF;Lindzen,EricC
ObjectiveRecent neuropathological studies have reported that late-onset schizophrenia patients exhibit a restricted limbic tauopathy, glial tangles (thorn-shaped astrocytes), scarce amyloid deposition, and preservation of hippocampal pyramidal cells. The present article is an attempt at finding a macroscopic correlate to the described pathology.MethodsA group of 13 normal-onset (< 40 years) schizophrenic patients, 13 late-onset (> 40 years) schizophrenia patients, and 8 comparison clients were studied, based on fulfillment of diagnostic criteria (eg, DSM-III) and availability of suitable tissue. A computerized image analysis provided areal measurements of the hippocampal formation. Both hemispheres and two levels (mammillary bodies and lateral geniculate nucleus) were studied. In order to avoid corrections based on tissue shrinkage, results were expressed as ratios (eg, parahippocampal gray/white matter).ResultsLate-onset schizophrenic patients exhibit significant alterations in the gray-/white-matter ratio of the parahippocampal gyrus, affecting both hemispheres and all levels examined. This finding can best be explained by the preservation of gray matter and concomitant reduction of white matter in affected parahippocampal gyri.ConclusionThe presence of neuritic changes, preservation of pyramidal cell numbers, and of areal diminution of the parahippocampal white matter can best be explained by a dying-back neuropathy.
