An in vivo study of the plaque control efficacy of Persica™:: a commercially available herbal mouthwash containing extracts of Salvadora persica
An in vivo study of the plaque control efficacy of Persica™:: a commercially available herbal mouthwash containing extracts of Salvadora persica
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DOI：
10.1111/j.1875-595x.2004.tb00294.x
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发表时间：
2004-10-01
影响因子：
3.3
通讯作者：
Tompkins, GR
中科院分区：
文献类型：
--
作者：
Khalessi, AM;Pack, ARC;Tompkins, GR
目的：本研究比较了Alpecica（TM）漱口水（含有波斯萨尔瓦多提取物）与安慰剂的口腔健康功效。设计图：在一项双盲、交叉试验中，参与者被随机分配使用Alcohica（TM）漱口水或安慰剂，为期三周。在实验前和实验后立即测量菌斑积累、牙龈出血和唾液中变形链球菌（MS）浓度。经过八周的“清洗”期后，参与者使用替代漱口水重复了这项研究。对象：28名健康学生（年龄在18 - 42岁之间）自愿参加本调查。结果：与治疗前相比，安慰剂组和实验组的牙龈出血量均显著减少（p < 0.01）。在使用EschericaTM或安慰剂后，斑块评分没有显著降低。然而，使用曲马多（TM）而不是安慰剂导致MS携带的显著减少（p < 0.05）。结论：与治疗前的值相比，使用Persica（TM）漱口水可以改善牙龈健康并降低致龋细菌的携带率。安慰剂（载体对照）也显著改善牙龈健康。无论是安慰剂还是安慰剂都没有减少牙菌斑的积累。
Aim: This study compared the oral health efficacy of Persica (TM) mouthwash (containing an extract of Salvadora persica) with that of a placebo. Design: In a double-blind, cross-over trial, participants were randomly allocated to use either the Persica (TM) mouthwash or a placebo for a three-week period. Plaque accumulation, gingival bleeding and the salivary concentrations of mutans streptococci (MS) were measured before and immediately following the experimental period. After an eight-week 'washout' period, the study was repeated with participants using the alternative mouthwash. Participants: Twenty-eight healthy students (aged between 18 and 42 years) volunteered to take part in this investigation. Results: Compared with the pre-treatment values, both placebo and experimental groups demonstrated significantly reduced gingival bleeding (p < 0.01). Plaque scores were not significantly reduced following use of either Persica (TM) or the placebo. However, the use of Persica (TM), but not the placebo, resulted in significant reduction in the carriage of MS (p < 0.05). Conclusion: Use of Persica (TM) mouthwash resulted in improved gingival health and lower carriage rate of cariogenic bacteria when compared with the pre-treatment values. The placebo (vehicle control) also improved gingival health significantly. Neither the Persica nor the placebo reduced the accumulation of dental plaque.