DECREASED INCIDENCE OF INDOMETHACIN-INDUCED GASTRIC ULCERATION IN RATS BY BILE-DUCT DIVERSION
DECREASED INCIDENCE OF INDOMETHACIN-INDUCED GASTRIC ULCERATION IN RATS BY BILE-DUCT DIVERSION
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DOI：
10.1002/bjs.1800620208
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发表时间：
1975-01-01
影响因子：
9.6
通讯作者：
DJAHANGUIRI, B
中科院分区：
文献类型：
--
作者：
ABTAHI, FS;DJAHANGUIRI, B
腹腔注射吲哚美辛（40 mg/kg），造成大鼠胃粘膜溃疡。随着胆汁流逐渐转向乏特壶腹远端，溃疡的发生率逐渐降低。提示胆汁反流入胃可能在消炎痛性胃溃疡的发病机制中起一定作用。
Gastric mucosal ulceration was produced in rats following intraperitoneal injection of indomethacin (40 mg/kg). The incidence of ulcerations was progressively reduced as the bile flow was diverted progressively distal to the ampulla of Vater. It is suggested that bile reflux into the stomach may play a part in the pathogenesis of indomethacin-induced gastric ulceration in rats.