Editorial: A humble way forward amid hype and hope.
Editorial: A humble way forward amid hype and hope.
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社论：在炒作和希望中谦虚地前进。
DOI：
10.1097/mnh.0000000000000720
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发表时间：
2021
影响因子：
3.2
通讯作者：
Martin,Aline
中科院分区：
文献类型：
--
作者：
Isakova,Tamara;Martin,Aline
生物医学研究是一项具有挑战性的业务。科学家们长时间致力于研究问题，希望推进他们的领域和/或解决未满足的临床需求。当发现确实发生时，尽管最初的兴奋可能会导致炒作，但未能完成后续的验证和翻译步骤可能会削弱热情，有时甚至导致方向的改变。在短时间内，COVID-19 大流行清楚地表明了在寻找证据时保持谦逊的重要性。本期《肾病学和高血压现状观点》矿物质代谢部分的收藏提供了近期发现之旅中的一系列例子，提醒我们在炒作中保持谦虚，并激励我们在努力缩小转化研究差距时继续抱有希望。围绕维生素 D 有益作用的炒作早于 COVID-19 大流行。将低维生素 D 水平与 COVID-19 联系起来的假设是基于 Szeto 等人在评论中精心阐述的科学原理而出现的。（第 387-396 页）正如他们在文章中所讨论的，已经报道了许多观察性研究，但结果好坏参半。迄今为止，一项阴性随机临床试验已经发表，其他试验正在进行中。作者恰当地指出了已发表的流行病学文献中重要的方法学局限性，并建议特别需要研究评估维生素 D 补充剂对慢性肾病 (CKD) 人群的影响，因为这一高危人群维生素 D 缺乏症的患病率很高。
Biomedical investigation is a challenging business. Scientists labor for extended periods of time on questions with the hope of advancing their fields and/or addressing an unmet clinical need. When discoveries do happen, although the initial excitement can lead to hype, failure to traverse the subsequent validation and translation steps can temper enthusiasm and at times even lead to a change in direction. In a short period of time, the COVID-19 pandemic has clearly demonstrated the importance of humility in the search for evidence. The collections in this edition of the Mineral Metabolism section in the Current Opinion in Nephrology and Hypertension provide a set of examples in recent discovery journeys that remind us to be humble amid hype and inspire us to continue to hope as we push to narrow translational research gaps.The hype around beneficial effects of vitamin D precedes the COVID-19 pandemic. Hypotheses linking low Vitamin D levels with COVID-19 emerged based on the scientific rationales nicely laid out in the review by Szeto et al.(pp. 387–396) As discussed in their piece, many observational studies have been reported, with mixed results. To date, a single negative randomized clinical trial has been published, and others are ongoing. The authors appropriately point out important methodologic limitations in the published epidemiologic literature and suggest that studies evaluating the effects of vitamin D supplementation in the chronic kidney disease (CKD) population are especially needed, given the high prevalence of Vitamin D deficiency in this high-risk group.