FORMALDEHYDE (CH2O) CONCENTRATIONS IN THE BLOOD OF HUMANS AND FISCHER-344 RATS EXPOSED TO CH2O UNDER CONTROLLED CONDITIONS
FORMALDEHYDE (CH2O) CONCENTRATIONS IN THE BLOOD OF HUMANS AND FISCHER-344 RATS EXPOSED TO CH2O UNDER CONTROLLED CONDITIONS
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DOI：
10.1080/15298668591394275
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
TOSUN, T
中科院分区：
文献类型：
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作者：
HECK, HD;CASANOVASCHMITZ, M;TOSUN, T
测定了暴露于甲醛（CH2O）对血液中CH2O浓度的影响。8只雄性F-344大鼠暴露于14.4.+-。2.4 ppm CH2O 2 h，暴露后立即采集血液。通过气相色谱/质谱法测定血液中的甲醛浓度。以相同的方式收集8只未暴露于CH2O的大鼠的血液并进行分析。测量的CH2O浓度（μ g/g血液）为：对照，2.24 ±。0.07;暴露，2.25. ±. 0.07（平均值±）。SE）。通过分析6名志愿者（4男2女）暴露于1.9 ± 1.5 μ g/ml甲醛之前和之后采集的静脉血样品，测定人血液中的甲醛浓度。0.1平均CH2O浓度（μ g/g血液）为：暴露前，2.61 ± 0.00ppm。0.14;暴露后，2.77 ±。0.28.在这两项实验中，接触对血液中的平均CH2O浓度没有统计学显著影响。人类受试者的血液中CH2O浓度存在显著差异，在某些受试者暴露前后采集的血液中CH2O浓度存在显著差异（增加或减少），表明血液中CH2O浓度可能随时间而变化。
The effect of exposure to formaldehyde (CH2O) on the CH2O concentration of the blood was determined. Eight male F-344 rats were exposed to 14.4 .+-. 2.4 ppm CH2O for 2 h and the blood was collected immediately after exposure. Formaldehyde concentrations in the blood were determined by gas chromatography/mass spectrometry. The blood of 8 rats unexposed to CH2O was collected and analyzed in the same manner. Measured CH2O concentrations (.mu.g/g blood) were: controls, 2.24 .+-. 0.07; exposed, 2.25 .+-. 0.07 (mean .+-. SE). Formaldehyde concentrations in human blood were determined by analyzing samples of venous blood collected before and after exposure of 6 human volunteers (4 male 2 female) to 1.9 .+-. 0.1 ppm CH2O for 40 min. Average CH2O concentrations (.mu.g/g blood) were: before exposure, 2.61 .+-. 0.14; after exposure, 2.77 .+-. 0.28. In neither experiment was there a statistically significant effect of exposure on the average CH2O concentration of the blood. Human subjects differed significantly with respect to their blood CH2O concentrations and significant differences (an increase or decrease) were found between the CH2O concentrations of the blood taken before and after exposure from some subjects, suggesting that blood CH2O concentrations may have varied with time.