Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism.
Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism.
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大鼠模型中暴露于环境颗粒物诱发慢性阻塞性肺病及其潜在机制的描述
DOI：
10.1038/srep45666
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发表时间：
2017-03-31
影响因子：
4.6
通讯作者：
Ran P
中科院分区：
文献类型：
--
作者：
He F;Liao B;Pu J;Li C;Zheng M;Huang L;Zhou Y;Zhao D;Li B;Ran P
虽然空气污染对健康的影响至少自1950年代以来一直是国际公共卫生问题，但最近的研究集中在两大空气污染源，即生物质燃料（BMF）和机动车尾气（MVE）。许多研究表明，空气污染PM与既存COPD恶化之间存在关联，但空气污染PM在COPD发展和进展中的作用仍不确定。目前的研究表明，大鼠在长期暴露于空气污染PM（BMF和MVE）后可以发展明显的COPD，其特征在于肺功能降低、粘液化生、肺和全身炎症、肺气肿和小气道重塑。比较分析表明，BMF和MVE激活与COPD发展相关的相似发病机制。这些结果还表明，在暴露于BMF或MVE的大鼠肺中发现了一些差异，这可能导致不同的COPD表型。
While the health effects of air pollution have been an international public health concern since at least the 1950s, recent research has focused on two broad sources of air pollution, namely, biomass fuel (BMF) and motor vehicle exhaust (MVE). Many studies have shown associations between air pollution PM and exacerbations of pre-existing COPD, but the role of air pollution PM in the development and progression of COPD is still uncertain. The current study indicates that rats can develop pronounced COPD following chronic exposure to air pollution PM (BMF and MVE), as characterized by lung function reduction, mucus metaplasia, lung and systemic inflammation, emphysema, and small airway remodeling. Comparative analyses demonstrate that both BMF and MVE activate similar pathogenesis that are linked to the development of COPD. These findings also show that some differences are found in the lungs of rats exposed to BMF or MVE, which might result in different phenotypes of COPD.