DREAM target reactivation by core transcriptional regulators supports neuroblastoma growth
DREAM target reactivation by core transcriptional regulators supports neuroblastoma growth
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DOI：
10.1080/23723556.2019.1565470
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发表时间：
2019-01-01
影响因子：
2.1
通讯作者：
Speleman, Frank
中科院分区：
文献类型：
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作者：
Decaesteker, Bieke;De Preter, Katleen;Speleman, Frank
染色体17 q增益是一种常见的改变，在高危神经母细胞瘤与未知的功能意义。我们鉴定了17 q超级增强子调节的T-box转录因子2（TBX 2）作为通过增强V-myc骨髓细胞瘤病病毒相关癌基因、成神经细胞瘤衍生（禽类）（MYCN）/叉头盒蛋白M1（FOXM 1）二聚化伴侣、RB样、E2 F和多外阴B类（DREAM）靶点的再活化来驱动增殖的核心调节回路的组成部分，其可通过组合的细胞周期蛋白依赖性激酶7和溴结构域抑制而协同影响。
Chromosome 17q gains are a common alteration in high-risk neuroblastomas with unknown functional significance. We identified a 17q super-enhancer regulated T-box Transcription Factor 2 (TBX2) as constituent of a core regulatory circuitry driving proliferation through enhancing V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived (avian) (MYCN)/Forkhead box protein M1(FOXM1) reactivation of dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) targets, which can be affected synergistically by combined cyclin-dependent kinase 7 and Bromo-domain inhibition.