Macrophage activation and polarization in post-infarction cardiac remodeling.
Macrophage activation and polarization in post-infarction cardiac remodeling.
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DOI：
10.1186/s12929-017-0322-3
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发表时间：
2017-02-07
影响因子：
11
通讯作者：
Ryabov V
中科院分区：
文献类型：
--
作者：
Gombozhapova A;Rogovskaya Y;Shurupov V;Rebenkova M;Kzhyshkowska J;Popov SV;Karpov RS;Ryabov V
不良心脏重构导致心室功能受损和心力衰竭，仍然是急性心肌梗死患者死亡和发病的主要原因。研究表明，即使对ST段抬高型心肌梗死进行了所有推荐的治疗，仍有三分之一的患者发生进行性心脏重塑，这是心力衰竭的形态学基础。需要扩大我们的知识的因素，导致不同的临床情况下的心肌梗死和以下并发症，导致了研究的免疫炎症途径和分子活动的基础上梗死后重塑。最近，巨噬细胞（先天免疫系统的细胞）已成为在正常和病理条件下的科学兴趣的主题。大环内酯除了在宿主保护和组织稳态中发挥作用外，在心肌梗死诱导的病理生理过程中发挥重要作用。在这篇文章中，我们总结了有关单核细胞和巨噬细胞可塑性在心肌梗死中的功能的数据，并概述了这些细胞作为控制急性冠状动脉事件后的炎症、心脏重塑和愈合过程的有效靶点的潜在作用。
Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, even if all the recommended therapies for ST-segment elevation myocardial infarction are performed, one third of patients undergoes progressive cardiac remodeling that represents morphological basis for following heart failure. The need to extend our knowledge about factors leading to different clinical scenarios of myocardial infarction and following complications has resulted in a research of immuno-inflammatory pathways and molecular activities as the basis for post-infarction remodeling. Recently, macrophages (cells of the innate immune system) have become a subject of scientific interest under both normal and pathological conditions. Macrophages, besides their role in host protection and tissue homeostasis, play an important role in pathophysiological processes induced by myocardial infarction. In this article we summarize data about the function of monocytes and macrophages plasticity in myocardial infarction and outline potential role of these cells as effective targets to control processes of inflammation, cardiac remodeling and healing following acute coronary event.