3D ultrafast ultrasound imaging in vivo.
3D ultrafast ultrasound imaging in vivo.
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DOI：
10.1088/0031-9155/59/19/l1
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发表时间：
2014-10-07
影响因子：
3.5
通讯作者：
Pernot M
中科院分区：
文献类型：
--
作者：
Provost J;Papadacci C;Arango JE;Imbault M;Fink M;Gennisson JL;Tanter M;Pernot M
超高帧率超声成像最近使得回波描记术的应用扩展到新的研究领域，例如大脑功能成像、心脏电生理学以及肿瘤内在机械特性的定量实时成像等，仅举几例，非侵入性实时成像。在这项研究中，我们基于使用从探头后面的稀疏虚拟阵列发出的发散波或平面波，首次实现了三维超快超声成像。它实现了高对比度和分辨率，同时保持每秒数千卷的成像速率。开发了定制的便携式超声系统，可对 1024 个独立通道进行采样并驱动 32×32 矩阵阵列探头。其在单次超快采集中跟踪毫秒范围内发生的 3D 瞬态现象的能力已在 3D 剪切波成像、3D 超快多普勒成像以及最终的 3D 超快组合组织和血流多普勒中得到证明。在体模中跟踪剪切波的传播并用于表征其刚度。 3-D 超快多普勒用于在单次采集中获得脉冲多普勒、彩色多普勒和能量多普勒量的 3-D 图，并首次揭示了整个心动周期期间人类心脏心室中发生的复杂 3-D 血流模式，以及颈动脉分叉处脉搏波期间血流与室壁运动的 3-D 体内相互作用。这项研究展示了 3D 超快超声成像在人体体内硬度、组织运动和血流的 3D 实时绘图方面的潜力，并有望在减少观察者内和观察者间差异的情况下实现超声的新临床应用。
Very high frame rate ultrasound imaging has recently allowed for the extension of the applications of echography to new fields of study such as the functional imaging of the brain, cardiac electrophysiology, and the quantitative real-time imaging of the intrinsic mechanical properties of tumors, to name a few, non-invasively and in real time. In this study, we present the first implementation of Ultrafast Ultrasound Imaging in three dimensions based on the use of either diverging or plane waves emanating from a sparse virtual array located behind the probe. It achieves high contrast and resolution while maintaining imaging rates of thousands of volumes per second. A customized portable ultrasound system was developed to sample 1024 independent channels and to drive a 32×32 matrix-array probe. Its capability to track in 3D transient phenomena occurring in the millisecond range within a single ultrafast acquisition was demonstrated for 3-D Shear-Wave Imaging, 3-D Ultrafast Doppler Imaging and finally 3D Ultrafast combined Tissue and Flow Doppler. The propagation of shear waves was tracked in a phantom and used to characterize its stiffness. 3-D Ultrafast Doppler was used to obtain 3-D maps of Pulsed Doppler, Color Doppler, and Power Doppler quantities in a single acquisition and revealed, for the first time, the complex 3-D flow patterns occurring in the ventricles of the human heart during an entire cardiac cycle, and the 3-D in vivo interaction of blood flow and wall motion during the pulse wave in the carotid at the bifurcation. This study demonstrates the potential of 3-D Ultrafast Ultrasound Imaging for the 3-D real-time mapping of stiffness, tissue motion, and flow in humans in vivo and promises new clinical applications of ultrasound with reduced intra- and inter-observer variability.