Increased c-fos-like immunoreactivity in the superior colliculus and lateral geniculate nucleus of the rd mouse.
Increased c-fos-like immunoreactivity in the superior colliculus and lateral geniculate nucleus of the rd mouse.
复制标题
rd 小鼠上丘和外侧膝状核中 c-fos 样免疫反应性增加。
DOI：
10.1016/j.brainres.2004.06.081
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Lund,Raymond
中科院分区：
文献类型：
--
作者：
Lu,Bin;Coffey,Peter;Lund,Raymond
在黑暗中维持一段时间的正常小鼠的大多数皮层下视觉中心，很少有神经元表达Fos样免疫反应性（FLI），最有可能反映c-fos表达，但如果动物暴露于闪光灯下，FLI表达细胞的数量会短暂增加。在具有遗传性光感受器缺陷的暗维持视网膜变性（rd）小鼠中，免疫化学鉴定的FLI阳性细胞的数量在上级丘（SC）和外侧膝状体核（LGN）中显著升高。眼球摘除在很大程度上防止了计数升高。rd小鼠和非营养不良对照组SC中FLI阳性细胞数量的差异非常显著（p<0.001）。因为我们以前在皇家外科学院（RCS）大鼠中发现了类似的现象，其中感光细胞的丧失是由视网膜色素细胞缺陷引起的，所以它认为感光细胞丧失的影响而不是其原因。
In most subcortical visual centers in normal mice maintained for a period in the dark, very few neurons express fos-like immunoreactivity (FLI), most likely reflecting c-fos expression, but if an animal is exposed to a flashing light, there is transient increase in the number of FLI-expressing cells. In dark-maintained retinal degeneration (rd) mice, with an inherited photoreceptor defect, numbers of FLI-positive cells, identified immunohistochemically, are anomalously elevated in the superior colliculus (SC) and lateral geniculate nucleus (LGN). Eye removal largely prevents the elevated counts. The difference in number of FLI-positive cells in the SC of rd mice and nondystrophic controls is highly significant (p<0.001). Because we have previously found a similar phenomenon in Royal College of Surgeons (RCS) rats, in which photoreceptor loss is caused by a retinal pigment cell defect, it argues for an effect related to photoreceptor loss rather than its cause.