Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET
Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET
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DOI：
10.1016/j.neuroimage.2016.09.028
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发表时间：
2016-12-01
期刊：
影响因子：
5.7
通讯作者：
Itco, Hiroshi
中科院分区：
文献类型：
--
作者：
Matsubara, Keisuke;Ibaraki, Masanobu;Itco, Hiroshi
由于部分容积效应，[C-11]匹兹堡化合物B（[C-11]PiB）在白色中的非特异性高摄取和来自白色的信号溢出混淆了正电子发射断层扫描（PET）中测量的放射性与[C-11]PiB。我们的目的是揭示[C-11]PiB的动力学参数的绝对值的部分体积效应，从白色物质的溢出。通过基于区域和基于体素的部分体积校正，对5名健康志愿者和8名阿尔茨海默病患者进行[C-11]PiB PET扫描中获取的动态数据进行了校正。结合电位（BPND）估计使用两个组织房室模型分析与血浆输入功能。部分容积校正显著降低皮质BPND值。健康志愿者的下降程度（-52.7 +/-5.8%）大于阿尔茨海默病患者（-11.9 +/-4.2%）。模拟结果表明，由于部分容积效应导致的白色物质溢出信号导致皮质BPND的高估，并且对于较低的BPND值具有更大程度的高估。因此，部分容积效应导致的高估在健康志愿者中比在阿尔茨海默病患者中更严重。部分体积校正可用于准确定量皮质区域中的A β沉积。(C)2016作者爱思唯尔公司出版。这是CC BY许可下的开放获取文章。
High non-specific uptake of [C-11]Pittsburgh compound B ([C-11]PiB) in white matter and signal spillover from white matter, due to partial volume effects, confound radioactivity measured in positron emission tomography (PET) with [C-11]PiB. We aimed to reveal the partial volume effect in absolute values of kinetic parameters for [C-11]PiB, in terms of spillover from white matter. Dynamic data acquired in [C-11]PiB PET scans with five healthy volunteers and eight patients with Alzheimer's disease were corrected with region-based and voxel-based partial volume corrections. Binding potential (BPND) was estimated using the two-tissue compartment model analysis with a plasma input function. Partial volume corrections significantly decreased cortical BPND values. The degree of decrease in healthy volunteers (-52.7 +/- 5.8%) was larger than that in Alzheimer's disease patients (-11.9 +/- 4.2%). The simulation demonstrated that white matter spillover signals due to the partial volume effect resulted in an overestimation of cortical BPND, with a greater degree of overestimation for lower BPND values. Thus, an overestimation due to partial volume effects is more severe in healthy volunteers than in Alzheimer's disease patients. Partial volume corrections may be useful for accurately quantifying A beta deposition in cortical regions. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.