Sex differences in cannabis forms and exposure reasons in cannabis-related poison control center cases aged 50.
Sex differences in cannabis forms and exposure reasons in cannabis-related poison control center cases aged 50.
复制标题
50岁大麻相关毒物控制中心病例中大麻形式的性别差异及暴露原因。
DOI：
10.1080/15563650.2020.1869756
复制
发表时间：
2021
期刊：
影响因子：
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通讯作者：
Baker,SDavid
中科院分区：
文献类型：
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作者：
Choi,NamkeeG;DiNitto,DianaM;Marti,CNathan;Baker,SDavid
Context/ObjectivesA significant proportion of individuals aged 50+ in the U.S. use cannabis for medical or recreational purposes, sometimes with adverse effects. Given differences in cannabis use among men and women, we examined sex differences in (1) cannabis forms used, (2) exposure reasons, and (3) medical outcomes in older-adult poison control center (PCC) cases.MethodsData came from the American Association of Poison Control Centers’ National Poison Data System, 2009–2019. We focused on the 3633 cases aged 50+ in which plant and other non-synthetic cannabinoid cannabis forms were the only or primary substance. Logistic regression was used to examine associations of sex with cannabis forms. Multinomial logistic regression models were fit to examine associations of sex with exposure reasons (therapeutic errors/adverse reactions, intentional misuse/abuse, other) and medical outcomes (no-to-minimal, moderate, or major effects).ResultsFemales constituted 57.4% of cases. In multivariable analyses, female cases had 1.20 (95% CI = 1.01–1.43) greater odds of involving cannabis forms other than plant forms and 1.93 greater odds (95% CI = 1.66–2.24) of therapeutic errors/adverse effects compared to intentional misuse/abuse. Older age and occurrence in recreational-cannabis-legal states were positively associated with other cannabis forms. Older age, recreational and/or medical cannabis-legal states, CBD, pharmaceuticals, concentrated extracts, and chronic exposure were associated with higher odds of therapeutic errors/adverse effects. Sex was not significantly associated with medical outcomes.ConclusionsFemale cases compose a large share of PCC cases aged 50+ and are associated with higher odds of involving cannabis forms other than plants and therapeutic errors/adverse reactions compared to intentional misuse/abuse.
