Protective roles of bioactive peptides during ischemia-reperfusion injury: From bench to bedside
Protective roles of bioactive peptides during ischemia-reperfusion injury: From bench to bedside
复制标题
生物活性肽在缺血再灌注损伤中的保护作用：从实验室到临床
DOI：
10.1016/j.lfs.2017.05.014
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发表时间：
2017
期刊：
影响因子：
6.1
通讯作者：
Yanzhang Li
中科院分区：
文献类型：
--
作者：
Dongdong Wu;Jun Wang;Honggang Wang;Ailing Ji;Yanzhang Li
缺血再灌注（I/R）是一种众所周知的病理状态，可导致残疾和死亡。I/R损伤在许多临床情况下仍然是一个未解决的和复杂的情况，例如成功复苏的心脏骤停，以及脑和心脏的缺血事件。肽类化合物具有低毒性、低免疫原性、良好的溶解性、独特的组织分布模式和良好的药代动力学特征等优点，是治疗I/R损伤的理想药物。越来越多的研究表明，肽可以保护许多不同器官和组织免受I/R损伤。肽还面临限制其临床应用的若干治疗挑战。本文综述了多肽在减轻I/R损伤中的作用机制，并进一步讨论了改善生物活性肽功能特性的修饰策略。
Ischemia-reperfusion (I/R) is a well-known pathological condition which may lead to disability and mortality. I/R injury remains an unresolved and complicated situation in a number of clinical conditions, such as cardiac arrest with successful reanimation, as well as ischemic events in brain and heart. Peptides have many attractive advantages which make them suitable candidate drugs in treating I/R injury, such as low toxicity and immunogenicity, good solubility property, distinct tissue distribution pattern, and favorable pharmacokinetic profile. An increasing number of studies indicate that peptides could protect against I/R injury in many different organs and tissues. Peptides also face several therapeutic challenges that limit their clinical application. In this review, we present the mechanisms of action of peptides in reducing I/R injury, as well as further discuss modification strategies to improve the functional properties of bioactive peptides.