Age and target organ damage in essential hypertension: Role of the metabolic syndrome
Age and target organ damage in essential hypertension: Role of the metabolic syndrome
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DOI：
10.1016/j.amjhyper.2006.09.010
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发表时间：
2007-03-01
影响因子：
3.2
通讯作者：
Mancia, Giuseppe
中科院分区：
文献类型：
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作者：
Cuspidi, Cesare;Meani, Stefano;Mancia, Giuseppe
目的：我们试图研究代谢综合征（MS）与原发性高血压患者心血管改变与年龄的关系。方法：将3266例未经治疗和治疗的高血压患者分为3个年龄组（1∶17 ~ 40岁；11∶41 ~ 64岁；3∶60 ~ 64岁）进行分析。所有患者都进行了广泛的检查，寻找靶器官损伤（TOD）。质谱根据先进技术实验室（ATP） III标准定义。结果：在整个人群中，在MS存在的情况下，左心室肥厚（LVH）、颈动脉异常和微量白蛋白尿的风险分别增加了2.5倍（P = 0.003）、2.2倍（P = 0.005）和1.5倍（P = 0.01）。LVH患病率(I组：39% vs 22%； II组：53% vs 35%； III组：69% vs 52%， P
Objective: We sought to investigate the association of the metabolic syndrome (MS) with cardiovascular alterations in essential hypertensives in relation to age.Methods: A total of 3266 untreated and treated hypertensive patients categorized in three age groups (1: 17 to 40 years; 11: 41 to 64 years; III: > 64 years) were considered for this analysis. All patients underwent extensive investigations searching for target organ damage (TOD). The MS was defined according to Advanced Technology Laboratories (ATP) III criteria.Results: In the entire population, the risk of left ventricular hypertrophy (LVH), carotid abnormalities, and microalbuminuria increased by 2.5 (P =.003), 2.2 (P = .005), and 1.5 times (P =.01), respectively, in the presence of MS after adjusting for several confounders. Prevalence of LVH (group I: 39% v 22%; group II: 53% v 35%; group III: 69% v 52%, P