PENICILLIN THERAPY IN ICTERIC LEPTOSPIROSIS
PENICILLIN THERAPY IN ICTERIC LEPTOSPIROSIS
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DOI：
10.4269/ajtmh.1988.39.388
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发表时间：
1988-10-01
影响因子：
3.3
通讯作者：
CALLENDER, J
中科院分区：
文献类型：
--
作者：
EDWARDS, CN;NICHOLSON, GD;CALLENDER, J
1983年10月1日至1986年12月31日进行了一项青霉素治疗黄疸人类钩端螺旋体病的前瞻性对照随机研究。38例患者接受5天静脉注射结晶青霉素，41例患者作为对照组，仅接受静脉输液。入院当天进行的实验室检查结果比较显示两组之间没有差异。两组患者退热时间、生化指标恢复正常、虹膜炎发生率、病死率差异无统计学意义。对照组3例（7.3%）死亡，治疗组1例（2.6%）死亡。总死亡率为5.9%。6例对照患者尿液培养中检出钩端螺旋体，治疗后培养中未检出钩端螺旋体。我们认为青霉素对黄疸钩端螺旋体病的临床预后影响不大。
A prospective, controlled randomized study of penicillin therapy in icteric human leptospirosis was carried out between 1 October 1983 and 31 December 1986. Thirty-eight patients received intravenous crystalline penicillin for 5 days, while 41 assigned to a control group received intravenous fluids only. A comparison of the results of laboratory tests made on the day of admission revealed no differences between the 2 groups. There was no significant difference in time for defervescence, return of biochemical parameters to normal, incidence of iritis, or mortality in the 2 groups. Three patients (7.3%) in the control group and 1 patient (2.6%) in the treatment group died. The overall mortality rate was 5.9%. Leptospira were recovered from urine cultures in 6 control patients but from none of the treated patients'' post-treatment cultures. We conclude that penicillin has little effect on clinical outcome in icteric leptospirosis.