Expression patterns of jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development
Expression patterns of jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development
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DOI：
10.1006/mcne.1996.0040
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发表时间：
1996-01-01
影响因子：
3.5
通讯作者：
Weinmaster, G
中科院分区：
文献类型：
--
作者：
Lindsell, CE;Boulter, J;Weinmaster, G
Notch 基因编码调节神经发生的信号通路的受体。 DSL (Delta/Serrate/lag-2) 基因编码结合并激活 Notch 的配体。原位杂交用于测定Notch1、Notch2和Notch3以及DSL配体Jagged和Delta1的时空表达，以鉴定在大鼠神经系统发育过程中起作用的潜在配体-受体对。在这里，我们描述了这些基因在形成中枢神经系统和周围神经系统的神经祖细胞中的不同和重叠的表达模式。我们检测到的 Jagged 和 Delta1 点状表达模式与它们在介导侧向抑制中的作用一致，侧向抑制是调节神经决定的过程。此外，在神经管和视网膜的心室区内，Jagged 和 Delta1 在互补区域表达，表明不同的 DSL-Notch 组合可能指导不同神经亚型的发育。
Notch genes encode receptors for a signaling pathway that regulates neurogenesis. The DSL (Delta/Serrate/lag-2) genes encode ligands that bind and activate Notch. In situ hybridization was used to determine the spatiotemporal expression of Notch1, Notch2, and Notch3, and the DSL ligands, Jagged and Delta1, in an effort to identify potential ligand-receptor pairs that function during development of the rat nervous system. Here we describe both distinct and overlapping expression patterns for these genes in neural progenitors that form both the central and the peripheral nervous systems. The punctate expression patterns we detected for Jagged and Delta1 are consistent with their role in mediating lateral inhibition, a process proposed to regulate neural determination. Furthermore, within the ventricular zone of the neural tube and retina, Jagged and Delta1 were expressed in complementary regions, suggesting that different DSL-Notch combinations may direct the development of distinct neural subtypes.