Vacuolar dynamics during the morphogenetic transition in Candida albicans.

Vacuolar dynamics during the morphogenetic transition in Candida albicans.
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白色念珠菌形态发生转变过程中的液泡动力学。

DOI:
10.1111/j.1567-1364.2008.00447.x
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发表时间:
2008
影响因子:
3.2
通讯作者:
Veses V
Veses V
中科院分区:
生物学4区
文献类型:
--
作者:
Veses V

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Morphogenetic transitions between the yeast, pseudohyphal and true hyphal forms of the fungal pathogenCandida albicansare coordinated with the cell cycle. In true hyphae, large vacuoles are formed in subapical compartments that influence compartment size and hence cell cycle progression and branching frequency. Here, live-cell imaging techniques were applied to study the dynamic process of vacuolar segregation in the three different morphological forms ofC. albicans. We show the presence of a filamentous vacuole segregation structure in pseudohyphae and true hyphae that differs from that of a stream of vacuole vesicles typical of vacuole inheritance in yeast cells. In growing hyphae, retrograde transport of the vacuoles led to apparent capture and adhesion of vacuoles to supapical septa, and septation events sometimes led to the bisection of large vacuoles that occupied sites of cytokinesis. Inhibitor studies also demonstrated that vacuole motility inC. albicanswas actin dependent and microtubule independent.
真菌生长菌丝中多形性小管和液泡的动态连续体
DOI: --
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