AMELIORATIVE EFFECT OF EMBLICA OFFICINALIS AQUEOUS EXTRACT ON OCHRATOXIN-INDUCED LIPID PEROXIDATION IN THE KIDNEY AND LIVER OF MICE
AMELIORATIVE EFFECT OF EMBLICA OFFICINALIS AQUEOUS EXTRACT ON OCHRATOXIN-INDUCED LIPID PEROXIDATION IN THE KIDNEY AND LIVER OF MICE
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DOI：
10.2478/v10001-010-0009-4
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发表时间：
2010-01-01
影响因子：
2
通讯作者：
Verma, Ramtej
中科院分区：
文献类型：
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作者：
Chakraborty, Devjani;Verma, Ramtej
目的：本研究旨在探讨余甘子水提物对赭曲霉毒素诱导的小鼠肾脏和肝脏脂质过氧化反应是否具有改善作用。研究方法：成年雄性白化病小鼠经口给予50 μ g（LD，低剂量）和100 μ g（HD，高剂量）赭曲霉毒素/0.2 ml橄榄油/动物/天，持续45天。结果如下：结果显示，与橄榄油处理对照组的结果相比，两个器官中的脂质过氧化反应显著（p < 0.05）、剂量依赖性增加以及酶抗氧化剂（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和谷胱甘肽转移酶）和非酶抗氧化剂（谷胱甘肽和总抗坏血酸）活性降低。余甘子水提取物（2毫克/动物/天）和赭曲霉毒素的一段时间的45天的管理引起显着改善赭曲霉毒素诱导的小鼠肝脏和肾脏的脂质过氧化反应。
Objectives: The present study was an attempt at investigating whether the aqueous extract of Emblica officinalis may have an ameliorative effect on ochratoxin-induced lipid peroxidation in the kidney and liver of mice. Methods: Adult male albino mice were orally administered 50 mu g (LD, low dose) and 100 mu g (HD, high dose) of ochratoxin/0.2 ml of olive oil/animal/day for 45 days. Results: The results revealed a significant (p < 0.05), dose-dependent increase in lipid peroxidation as well as a decreased activity of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione transferase) and non-enzymatic antioxidants (glutathione and total ascorbic acid) in both the organs, as compared to the findings for olive oil-treated control group. Administration of Emblica officinalis aqueous extract (2 mg/animal/day) and ochratoxin for a period of 45 days caused a significant amelioration in the ochratoxin-induced lipid peroxidation in mouse liver and kidney.