The elevated markers of hypercoagulability in children with Henoch-Schonlein purpura
The elevated markers of hypercoagulability in children with Henoch-Schonlein purpura
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DOI：
10.1080/08880010590896251
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发表时间：
2005-01-01
影响因子：
1.7
通讯作者：
Ozkayin, N
中科院分区：
文献类型：
--
作者：
Yilmaz, D;Kavakli, K;Ozkayin, N
28名HSP患儿和79名健康儿童参加了研究。蛋白C、游离蛋白S和抗凝血酶活性、活化蛋白C抵抗、纤维蛋白原水平。检测HSP急性期和恢复期血浆D-二聚体、凝血酶-抗凝血酶复合物（达特）、凝血酶原片段1 + 2（PF 1 +2）、血管性血友病因子抗原（vWAg）及其活性（RiCof）。HSP患者急性期纤维蛋白原、D-二聚体、达特、PF 1 +2、vWAg、RiCof水平均显著高于恢复期和对照组。检测到疾病严重程度与TAF、PF 1 +2、vWAg和D-二聚体水平之间存在显著相关性。
Twenty-eight children with HSP and 79 healthy children were entered into study. Activities of protein C, free-protein S and antithrombin, activated protein C resistance, levels of fibrinogen. D-dimer, thrombin-antithrombin complex (TAT), prothrombin fragments 1 + 2 (PF1+2), and von Willrebrand factor antigen (vWAg) and its activity (RiCof) were investigated in acute and recovery phases of HSP and controls. Fibrinogen, D-dimer, TAT, PF1+2, vWAg, and RiCof levels in patients with HSP during the acute phase were significantly higher than those of recovery phase and of the controls. A significant correlation was detected between severity of disease and TAF, PF1+2, vWAg, and D-dimer levels.