DYNAMIC RECONFIGURATION OF BRAIN-STEM NEURAL ASSEMBLIES - RESPIRATORY PHASE-DEPENDENT SYNCHRONY VERSUS MODULATION OF FIRING RATES
DYNAMIC RECONFIGURATION OF BRAIN-STEM NEURAL ASSEMBLIES - RESPIRATORY PHASE-DEPENDENT SYNCHRONY VERSUS MODULATION OF FIRING RATES
复制标题
DOI：
10.1152/jn.1992.67.4.923
复制
发表时间：
1992-04-01
影响因子：
2.5
通讯作者：
GERSTEIN, GL
中科院分区：
文献类型：
--
作者：
LINDSEY, BG;HERNANDEZ, YM;GERSTEIN, GL
1. 这项工作的目的是确定脑干中线神经组件的结构是否在呼吸周期中发生变化。在麻醉、麻痹、双侧迷走神经切除、人工通气的猫中同时记录多个单一神经元的尖峰序列。采用交叉相关法和重力法对数据进行分析。从已知的包含同步放电神经元的八组神经元中，每组的连续样本显示出同步的时间变化。对短时间（< 200-s）的脉冲序列数据样本进行重力分析，发现有20对聚集粒子，这是在母体数据集（> 20 min）的互相关分析中没有预测到的。研究人员分析了29组同时监测的3到8个神经元，每组至少有两个同步放电的神经元，以寻找呼吸相依赖调节这种协调活动的证据。分别分析连续的交错吸气和呼气间隔的尖峰。11组的神经元对在吸气间期更同步；六组的配对在呼气期间更加同步。两组不同对在不同呼吸期同步。在26对表现出相位依赖性同步性差异的神经元中，有11对通过周期触发直方图或放电率方差分析来判断，没有一个神经元具有呼吸调节的放电率。呼吸相关脑干神经网络的结构随时间和呼吸阶段的变化而变化。个体放电速率无明显呼吸调节的神经元集体表现出脉冲同步的呼吸相位依赖性调节。这种涌现特性的发现提出了一种假设，即通过对共递质释放的微分控制，速率和同步“码”可以在协调的并行信道中复用。
1. The objective of this work was to determine whether configurations of midline brain stem neural assemblies change during the respiratory cycle.2. Spike trains of several single neurons were recorded simultaneously in anesthetized, paralyzed, bilaterally vagotomized, artificially ventilated cats. Data were analyzed with cross-correlational and gravity methods.3. Sequential samples from each of eight groups of neurons known to contain synchronously discharging neurons exhibited temporal variations in that synchrony.4. Gravity analysis of short (< 200-s) samples of spike train data revealed 20 pairs of clustered particles that were not predicted from cross-correlation analysis of the parent data sets (> 20 min).5. Twenty-nine groups of three to eight simultaneously monitored neurons, each with at least two synchronously discharging neurons, were analyzed for evidence of respiratory phase-dependent modulation of that coordinated activity. Spikes from successive interleaved inspiratory and expiratory intervals were analyzed separately.6. Neuron pairs in 11 groups were more synchronous during the inspiratory interval; six groups had pairs that were more synchronous during the expiratory period. In two groups, different pairs were synchronous in different respiratory phases. In 11 of the 26 pairs that exhibited phase-dependent differences in synchrony, neither neuron had a respiratory-modulated firing rate as judged by either the cycle-triggered histogram or an analysis of variance of their firing rates.7. Configurations of respiratory-related brain stem neural networks changed with time and the phases of breathing. Neurons with no apparent respiratory modulation of their individual firing rates collectively exhibited respiratory phase-dependent modulation of their impulse synchrony. The detection of this emergent property suggests the hypothesis that rate and synchrony "codes" may be multiplexed in coordinated parallel channels through differential control of cotransmitter release.