Evidence and impact of human papillomavirus latency.
Evidence and impact of human papillomavirus latency.
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DOI：
10.2174/1874357901206010198
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Gravitt, Patti E
中科院分区：
文献类型：
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作者：
Gravitt, Patti E
目前，科学界对于人乳头瘤病毒（HPV）感染能否形成潜伏期尚无共识。基于动物研究，提出了一种乳头瘤病毒潜伏期模型，其中乳头瘤病毒可以作为潜伏感染保留在基底上皮干细胞池中，并在干细胞分裂和一个子细胞致力于最终分化和诱导病毒生命周期时周期性地诱导重新激活。假设组织常驻记忆t细胞控制这些周期性的再激活事件，从而限制其持续时间。在本文中，证据从人类研究一致的这种模型乳头瘤病毒潜伏期进行综述。鉴于强有力的间接证据支持HPV感染的自然史，包括免疫控制的潜伏状态，HPV潜伏对高度感染和老龄化人群的长期影响可能需要更认真的评估。
At present, there is no consensus in the scientific community regarding the ability for human papillomavirus (HPV) infections to establish latency. Based on animal studies, a model of papillomavirus latency has been proposed in which papillomaviruses can be retained in the basal epithelial stem cell pool as latent infections and periodically induced to reactivate when the stem cell divides and one daughter cell is committed to terminal differentiation and induction of the viral life cycle. Tissue resident memory T-cells are hypothesized to control these periodic reactivation episodes and thus limit their duration. In this paper, evidence from human studies consistent with this model of papillomavirus latency is reviewed. Given the strong circumstantial evidence supporting a natural history of HPV infection which includes a immunologically controlled latent state, the longer term implications of HPV latency on a highly infected and aging population may warrant a more serious evaluation.