Advanced glycation end products: Key players in skin aging?
Advanced glycation end products: Key players in skin aging?
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DOI：
10.4161/derm.22028
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发表时间：
2012-07-01
期刊：
影响因子：
--
通讯作者：
Böhm M
中科院分区：
文献类型：
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作者：
Gkogkolou P;Böhm M
衰老是生物体随时间推移逐渐积累损伤，导致疾病和死亡的过程。近年来，衰老研究十分深入，旨在描述衰老的病理生理学特征，并寻找对抗与年龄相关疾病的方法。人们已经提出了各种衰老理论。近年来，晚期糖基化终末产物（AGEs）在这方面受到了特别关注。在糖尿病患者体内会大量形成AGEs，在衰老过程中的正常生物体中也会形成。它们在病因学上与许多糖尿病和与年龄相关的疾病有关。抑制AGE积累和信号传导的策略似乎在这些疾病中具有治疗潜力。然而，对于AGEs在皮肤衰老过程中的确切作用仍知之甚少。在这篇综述中，将对有关AGEs和皮肤衰老的现有文献进行综述。此外，还将讨论对皮肤衰老可能有益的现有和潜在的抗AGE策略。
Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particular attention in this context. AGEs are formed in high amounts in diabetes but also in the physiological organism during aging. They have been etiologically implicated in numerous diabetes- and age-related diseases. Strategies inhibiting AGE accumulation and signaling seem to possess a therapeutic potential in these pathologies. However, still little is known on the precise role of AGEs during skin aging. In this review the existing literature on AGEs and skin aging will be reviewed. In addition, existing and potential anti-AGE strategies that may be beneficial on skin aging will be discussed.