Investigating the Medial Temporal Lobe in Alzheimer's Disease and Mild Cognitive Impairment, with Turboprop Diffusion Tensor Imaging, MRI-volumetry, and T2-relaxometry
Investigating the Medial Temporal Lobe in Alzheimer's Disease and Mild Cognitive Impairment, with Turboprop Diffusion Tensor Imaging, MRI-volumetry, and T2-relaxometry
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DOI：
10.1007/s11682-007-9001-4
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发表时间：
2007-06-01
影响因子：
3.2
通讯作者：
Carew, John D.
中科院分区：
文献类型：
--
作者：
Arfanakis, Konstantinos;Gui, Minzhi;Carew, John D.
阿尔茨海默病（AD）的第一个神经病理学改变发生在内侧颞叶（MTLs）、内嗅皮层（EC）、穿通通路（PP）和海马。本研究的目的是调查AD和轻度认知功能障碍（MCI）患者MTL结构的微结构完整性，大小和T-2弛豫时间，使用MRI技术，免疫磁场不均匀性。获得了AD和MCI患者以及健康对照组的Turboprop-DTI和高分辨率解剖MRI数据。与其他技术相比，Turboprop-DTI在更多的AD患者MTL结构中检测到与AD相关的显著变化。与正常对照组相比，MCI和AD队列中特定MTL结构的平均扩散率和T-2弛豫时间均增加。因此，Turboprop-DTI和T-2-弛豫技术可能是研究AD早期神经病理改变的有价值的无创工具。
The first neuropathological alterations in Alzheimer's disease (AD) occur in the medial temporal lobes (MTLs), in the entorhinal cortex (EC), perforant pathway (PP), and hippocampus. The purpose of this study was to investigate the microstructural integrity, size, and T-2-relaxation times of MTL structures in patients with AD and mild cognitive impairment (MCI), using MRI techniques that are immune to magnetic field inhomogeneities. Turboprop-DTI and high-resolution anatomical MRI data were obtained on AD and MCI patients, and healthy controls. Significant AD-related changes were detected in more MTL structures of AD patients by means of Turboprop-DTI than with any other technique used. Mean diffusivity and T-2-relaxation times of specific MTL structures increased in both the MCI and AD cohorts when compared to normal controls. Therefore, Turboprop-DTI and T-2-relaxometry may be valuable non-invasive tools in the investigation of the early AD-related neuropathological alterations.