Application of gold nanoparticles in biomedical and drug delivery
Application of gold nanoparticles in biomedical and drug delivery
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DOI：
10.3109/21691401.2014.955107
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发表时间：
2016-01-02
影响因子：
5.8
通讯作者：
Akbarzadeh, Abolfazl
中科院分区：
文献类型：
--
作者：
Daraee, Hadis;Eatemadi, Ali;Akbarzadeh, Abolfazl
纳米颗粒是最简单的结构形式，尺寸在纳米(Nm)范围内。原则上，任何结构半径为100纳米的原子结合在一起的集合都可以被认为是纳米粒子。纳米技术提供了独特的方法来探测和控制发生在纳米级的各种生物和医学过程，并有望对生物学和医学产生革命性的影响。在医学中利用纳米技术的方法中，纳米颗粒具有一些独特的优势，如传感、图像增强和递送剂。有几种具有生物医学相关性的纳米颗粒可用，包括聚合物纳米颗粒、金属纳米颗粒、脂质体、胶束、量子点、树枝状大分子和纳米组件。为了进一步将纳米粒子应用于疾病诊断和治疗，重要的是这些系统具有生物相容性，并且能够在全身给药后识别体内特定的靶点。在这篇综述中，我们解释了金纳米颗粒的一些重要应用。
Nanoparticles are the simplest form of structures with sizes in the nanometer (nm) range. In principle any collection of atoms bonded together with a structural radius of < 100 nm can be considered nano particles. Nanotechnology offers unique approaches to probe and control a variety of biological and medical processes that occur at nanometer scales, and is expected to have a revolutionary impact on biology and medicine. Among the approaches for exploiting nanotechnology in medicine, nanoparticles offer some unique advantages as sensing, image enhancement, and delivery agents. Several varieties of nanoparticles with biomedical relevance are available including, polymeric nanoparticles, metal nanoparticles, liposomes, micelles, quantum dots, dendrimers, and nanoassemblies. To further the application of nanoparticles in disease diagnosis and therapy, it is important that the systems are biocompatible and capable of being functionalized for recognition of specific target sites in the body after systemic administration. In this review, we have explained some important applications of gold nanoparticles.