Prior episodes of sodium depletion increase the need-free sodium intake of the rat.
Prior episodes of sodium depletion increase the need-free sodium intake of the rat.
复制标题
先前发生的钠消耗增加了大鼠的不需要的钠摄入量。
DOI：
10.1037//0735-7044.103.1.186
复制
发表时间：
1989
影响因子：
1.9
通讯作者：
Epstein,AN
中科院分区：
文献类型：
--
作者：
Sakai,RR;Frankmann,SP;Fine,WB;Epstein,AN
先前的钠耗尽发作增加了大鼠每日3%的NaCl摄入量。在钠缺乏恢复后的3个月时间里，患者在摄入富含钠的食物、血浆钠浓度和肾功能正常的情况下，仍大量摄入钠。因此，每天增加的钠摄入量是不需要的。3% NaCl的无需用摄入量存在显著的性别差异。当雌性大鼠钠含量充足且处于衰竭状态时，它们会比雄性大鼠喝更多的盐。反复消耗会提高两性的无需要摄入量，但对女性的影响更大。血管紧张素II和醛固酮的血浆浓度在每次钠耗尽时显著升高，在钠耗尽期间和之后恢复到基础水平，并且不是多次钠耗尽大鼠长期增加不需要盐摄入量的原因。这些结果表明，在有重复钠消耗史的大鼠中，每天持续增加3%的NaCl摄入量是一种永久性的、非病理性的对咸味物质的贪欲增加，导致终生过量食用盐。（PsycINFO数据库记录(c) 2016 APA，版权所有）
Prior episodes of sodium depletion increase the daily 3% NaCl intake of rats. They ingest large volumes and continue to do so for as long as 3 months after recovery from sodium deficit while eating sodium-rich food and while plasma sodium concentration and renal function are normal. The increased daily intake of sodium is, therefore, need-free. There is a marked sex difference in the need-free intake of 3% NaCl. Female rats drink more salt than do male rats when they are sodium replete and depletion naive. Repeated depletions raise the need-free intakes of both sexes but the effect is greater in females. Plasma concentrations of angiotensin II and aldosterone, which are markedly elevated by each episode of sodium depletion, return to basal levels between and after depletions, and are not the cause of the chronically increased need-free salt intake of the multi-depleted rat. These results suggest that the persistent increase in daily 3% NaCl intake that occurs in the rat with a history of repeated sodium depletions is a permanent, nonpathological increase in avidity for the taste of salty substances that results in life-long overconsumption of salt.(PsycINFO Database Record (c) 2016 APA, all rights reserved)