The evolution of renal function and the incidence of end-stage renal disease in patients aged ≥50 years
The evolution of renal function and the incidence of end-stage renal disease in patients aged ≥50 years
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DOI：
10.1093/ndt/gfr659
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发表时间：
2012-06-01
影响因子：
6.1
通讯作者：
Degryse, Jan
中科院分区：
文献类型：
--
作者：
Van Pottelbergh, Gijs;Bartholomeeusen, Stephaan;Degryse, Jan
背景慢性肾脏病（CKD）的患病率很高，尤其是老年患者。为了确定进展为终末期肾病（ESRD）的危险因素，从基于初级保健的数据库中选择了一组年龄≥ 50岁且至少有4次血清肌酐测量结果可用的患者。计算估计肾小球滤过率（eGFR）的变化斜率（使用肾脏疾病饮食改良公式），ESRD定义为eGFR ≥ 80岁（与年龄50-64岁的患者相比）。女性（HR = 1.48）和糖尿病（HR = 1.20）、高血压（HR = 1.25）、高总胆固醇（HR = 1.28）或高低密度脂蛋白（LDL）胆固醇（HR = 1.39）患者发生ESRD的风险较高。基线eGFR、糖尿病、高胆固醇、高LDL、高血压和女性是发生ESRD的独立危险因素。基线年龄较大预示风险较低。
Background. The prevalence of chronic kidney disease (CKD) is high, especially among older patients.Methods. In order to identify risk factors for the evolution towards end-stage renal disease (ESRD), a cohort of patients >= 50 years of age for whom at least four serum creatinine measurements were available were selected from a primary care-based database. The slope of changes in estimated glomerular filtration rate (eGFR) (using the Modification of Diet in Renal Disease formula) was calculated, and ESRD was defined as eGFR = 80 years compared with patients aged 50-64 years). Females (HR = 1.48) and patients with diabetes (HR = 1.20), hypertension (HR = 1.25), high total cholesterol (HR = 1.28) or high low-density lipoprotein (LDL) cholesterol (HR = 1.39) were at higher risk for ESRD.Conclusions. Baseline eGFR, diabetes, high cholesterol, high LDL, hypertension and female gender are independent risk factors for developing ESRD. Older age at baseline predicts a lower risk.