Electro-acupuncture relieves chronic visceral hyperalgesia in rats
Electro-acupuncture relieves chronic visceral hyperalgesia in rats
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DOI：
10.1016/j.neulet.2004.11.018
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发表时间：
2005-03-07
影响因子：
2.5
通讯作者：
Wu, GC
中科院分区：
文献类型：
--
作者：
Cui, KM;Li, WM;Wu, GC
针灸治疗是治疗包括慢性内脏疼痛在内的疼痛最理想的选择之一，但其科学依据和作用规律在这一点上还不是很清楚。在这项研究中，我们使用肠易激综合征（IBS）模型（一种慢性内脏过敏模型）研究了电针（EA）对大鼠结肠直肠膨胀（CRD）刺激引起的慢性内脏疼痛的即时和累积效应。结果表明，EA可以显著降低在20,40,60和80mmhg强度的CRD刺激下异常升高的腹部退缩反射（AWR）评分和腹直肌肌电图（emg）的大小。反复EA治疗14天，EA对异常awr和emg的影响均在EA应用开始后2 ~ 4天出现，在8 ~ 12天逐渐增强至最大，并在EA治疗停止后持续5天。这些数据证明了电刺激可以有效治疗大鼠肠易激综合征模型相关的内脏痛，并为针灸治疗慢性内脏痛的临床提供了可能。2004爱思唯尔爱尔兰有限公司版权所有。
Acupuncture treatment is one of the most desirable choices for the management of pain including chronic visceral pain, but its scientific evidence and laws of action are not very clear at this point. In this study, we examined the immediate and cumulative effects of electroacupuncture (EA) on chronic visceral pain induced by colorectal distention (CRD) stimuli in rats using an irritable bowel syndrome (IBS) model (a chronic visceral hypersensitivity model). The results demonstrated that EA could significantly depress both abnormally increased abdominal withdrawal reflex (AWR) scores and the magnitude of electromyograms (EMGs) recorded from the rectus abdominis in response to CRD stimulation at strengths of 20, 40, 60, and 80 mmHg. Repeated EA treatment for 14 days showed that the effects of EA on both abnormal AWRs and EMGs appeared 2-4 days after the start of the EA application session, gradually enhanced to its maximum within 8-12 days, and lasted 5 days after EA treatment stopped. These data provide evidence that visceral pain associated with the rat IBS model can be effectively treated by EA and opens up the possibility of clinical treatment of chronic visceral pain with acupuncture. (C) 2004 Elsevier Ireland Ltd. All rights reserved.