Individually tailored light intervention through closed eyelids to promote circadian alignment and sleep health.
Individually tailored light intervention through closed eyelids to promote circadian alignment and sleep health.
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DOI：
10.1016/j.sleh.2014.12.009
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发表时间：
2015-03-01
期刊：
影响因子：
4.1
通讯作者：
Figueiro MG
中科院分区：
文献类型：
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作者：
Figueiro MG
在接近核心体温最低温度时，光在改变生物钟的时间方面最有效。本研究调查了在家庭环境中，在一组健康的老年人和患有早醒失眠症的人群中，在睡眠期早期通过闭上眼皮发出的蓝色闪光是否推迟了昼夜节律和睡眠。28名参与者(9名早醒失眠症患者)完成了一项为期8周的受试者内研究。参与者在两个基线周和一个干预周收集了两次数据。在干预周，参与者在睡眠时戴着闪烁的蓝色(主动)或闪烁的红色(对照)光面具。预计光照会推迟昼夜节律阶段。在每个基线和干预周结束时收集唾液样本进行暗淡褪黑素发作(DLMO)。在整个研究过程中收集了腕部活动记录仪和日光计，这是一种校准的光和活动量计。与基线相比，闪烁蓝光，而不闪烁红光，DLMO显著延迟(p<；0.05)。闪烁红光的平均±标准差相移(分钟)为0：06±0：30，闪烁蓝光的平均±标准差相移(分钟)为0：34±0：30。与第一天相比，在蓝光闪烁后的第七天，睡眠开始时间显著延迟(约46分钟)。光干预不影响睡眠效率。本研究论证了在睡眠期间通过闭上眼皮使用光线来促进昼夜节律调整和睡眠健康的可行性。
Light is most effective at changing the timing of the circadian clock when applied close to the core body temperature minimum. The present study investigated, in a home setting, if individually tailored light treatment using flashing blue light delivered through closed eyelids during the early part of the sleep period delayed circadian phase and sleep in a population of healthy older adults and in those suffering from early awakening insomnia. Twenty-eight participants (9 early awakening insomniacs) completed an 8-week, within-subjects study. Twice, participants collected data during two baseline weeks and one intervention week. During the intervention week, participants wore a flashing blue (active) or a flashing red (control) light mask during sleep. Light was expected to delay circadian phase. Saliva samples for dim light melatonin onset (DLMO) were collected at the end of each baseline and intervention week. Wrist actigraphy and Daysimeter, a calibrated light and activity meter, data were collected during the entire study. Compared to baseline, flashing blue light, but not flashing red light, significantly (p<0.05) delayed DLMO. The mean ± standard deviation phase shift (minutes) was 0:06 ± 0:30 for the flashing red light and 0:34 ± 0:30 for the flashing blue light. Compared to Day 1, sleep start times were significantly delayed (by approximately 46 minutes) at Day 7 after the flashing blue light. The light intervention did not affect sleep efficiency. The present study demonstrated the feasibility of using light through closed eyelids during sleep for promoting circadian alignment and sleep health.