Consolidation of memory for odour-reward association requires transient polysialylation of the neural cell adhesion molecule in the rat hippocampal dentate gyrus
Consolidation of memory for odour-reward association requires transient polysialylation of the neural cell adhesion molecule in the rat hippocampal dentate gyrus
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DOI：
10.1002/jnr.10758
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发表时间：
2003-11-15
影响因子：
4.2
通讯作者：
Regan, CM
中科院分区：
文献类型：
--
作者：
Foley, AG;Hedigan, K;Regan, CM
细胞粘附分子功能参与海马突触可塑性，并与记忆巩固有关。在齿状回的颗粒下区，神经元表达的多聚唾液酸化形式的神经细胞粘附分子（NCAM PSA）瞬时增加其频率在12小时posttraining时间在行为引起的应激刺激，如条件回避，水迷宫，恐惧条件范例。为了确定学习诱导的NCAM多聚唾液酸化调节是否仅限于应激范式，我们采用了基于奖励的气味辨别任务。动物表现出快速的收购和召回的潜伏期，以确定食物相关的气味和选择错误的数量这一任务。采用免疫组织化学方法来确定任务获取后NCAM PSA表达的变化。NCAM PSA免疫反应性在海马结构是最强烈的颗粒样神经元在齿状回的颗粒下区，其频率短暂增加，在12小时posttraining期间。NCAM PSA免疫反应神经元的瞬时增加的性质是无法区分的，观察到以下回避条件反射或空间学习，因为它发生在同一时间。NCAM PSA表达的瞬时增加被认为是为了促进树突状细胞对获得新的行为库的反应。(C)2003 Wiley-Liss，Inc.
Cell adhesion molecule function is involved in hippocampal synaptic plasticity and is associated with memory consolidation. At the infragranular zone of the dentate gyrus, neurons expressing the polysialylated form of the neural cell adhesion molecule (NCAM PSA) transiently increase their frequency at the 12-hr posttraining time in behaviours elicited by stressful stimuli, such as those associated with conditioned avoidance, water maze, and fear conditioning paradigms. To determine whether learning-induced modulation of NCAM polysialylation is limited to stressful paradigms, we employed a reward-based odour discrimination task. Animals show a rapid acquisition and recall of this task in terms of latency to identify the food-associated odour and the number of choice errors. Immunohistochemical procedures were employed to determine the change in NCAM PSA expression following task acquisition. NCAM PSA immunoreactivity in the hippocampal formation was most intense on the granule-like neurons in the infragranular zone of the dentate gyrus, and their frequency transiently increased in the 12-hr posttraining period. The nature of the transient increase in NCAM PSA-immunoreactive neurons was indistinguishable from that observed following avoidance conditioning or spatial learning, in that it occurred at the same time. The transient increase in NCAM PSA expression is suggested to facilitate dendritic elaboration in response to the acquisition of novel behavioural repertoires. (C) 2003 Wiley-Liss, Inc.