Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease
Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease
复制标题
DOI：
10.1016/s1357-2725(02)00015-8
复制
发表时间：
2002-06-01
影响因子：
4
通讯作者：
Lungarella, G
中科院分区：
文献类型：
--
作者：
Cocci, F;Miniati, M;Lungarella, G
肺间质蛋白水解增强是肺气肿发病的关键事件，肺气肿是慢性阻塞性肺疾病的主要组成部分。为了评估尿去氨酶和/或羟脯氨酸是否可以作为肺破坏的标志，我们研究了20例慢性阻塞性肺疾病患者和19例适当对照者24小时尿液收集样本中这些产物的尿排泄情况。对于去氨酶的测量，我们开发了一种新的间接竞争性酶联免疫吸附测定法。通过高分辨率计算机断层扫描（CT）测量肺气肿的程度。通过考虑肺？CT区
An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic obstructive pulmonary disease. To assess whether urinary desmosine and/or hydroxyproline may be used as a marker of lung destruction we studied urinary excretions of these products in 20 patients with chronic obstructive pulmonary disease and in 19 appropriate controls in 24 h urine collection samples. For desmosine measurements, we developed a new indirect competitive enzyme-Linked immunosorbentassay. The extent of emphysema was measured in high resolution computed tomography (CT) scans. by considering lung? area with CT numbers