Central nervous system projections to and from the commissural ganglion of the crab Cancer borealis
Central nervous system projections to and from the commissural ganglion of the crab Cancer borealis
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DOI：
10.1007/s00441-007-0398-2
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发表时间：
2007-06-01
影响因子：
3.6
通讯作者：
Nusbaum, Michael P.
中科院分区：
文献类型：
--
作者：
Kirby, Matthew S.;Nusbaum, Michael P.
高阶输入提供了重要的监管控制电机电路，但很少有细胞水平的研究，这样的输入已被执行。为了开始在可访问的模型系统中研究高阶神经元，我们在食道上神经节（脑）中定位了神经元，这些神经元是影响螃蟹北巨蟹座的口胃神经系统（STNS）中特征良好的运动回路的候选者。STNS是中枢神经系统的延伸，包括四个神经节，其中有一组调节食物摄取和加工的运动回路。这些运动回路由一组调节神经元局部调节，其中大部分位于成对的连合神经节（CoG）中。这些调节神经元被很好地定位以接收来自脑神经元的输入，因为环食管连合（CoC）将脑与CoG连接。我们已经进行了一系列CoC回填，以定位可能神经支配CoG的大脑神经元，因此这些神经元是影响STNS运动模式的候选神经元。大脑内CoC回填标记的神经元胞体聚集在解剖学定义的神经元区域的子集周围。我们同时定位了许多投射到大脑的CoG神经元。后一种途径可能包括提供关于正在进行的STNS活动的反馈的神经元。有趣的是，几乎所有这些大脑和CoG神经元都通过CoC的内侧投射。这项工作提供了一个初步的框架，为未来的研究，以确定高阶输入调节节奏运动模式的方式。
Higher-order inputs provide important regulatory control to motor circuits, but few cellular-level studies of such inputs have been performed. To begin studying higher-order neurons in an accessible model system, we have localized, in the supraesophageal ganglion (brain), neurons that are candidates for influencing the well-characterized motor circuits in the stomatogastric nervous system (STNS) of the crab Cancer borealis. The STNS is an extension of the central nervous system and includes four ganglia, within which are a set of motor circuits that regulate the ingestion and processing of food. These motor circuits are locally regulated by a set of modulatory neurons, most of which are located in the paired commissural ganglia (CoGs). These modulatory neurons are well-positioned to receive input from brain neurons because the circumesophageal commissures (CoCs) connect the brain with the CoGs. We have performed a series of CoC backfills to localize the brain neurons that are likely to innervate the CoGs and are, therefore, candidates for influencinng the STNS motor patterns. CoC backfill-labeled neuronal somata within the brain are clustered around a subset of anatomically defined neuropil regions. We have concomitantly localized many CoG neurons that project into the brain. This latter pathway presumably includes neurons that provide feedback regarding ongoing STNS activity. Interestingly, nearly all of these brain and CoG neurons project through the medial aspect of the CoC. This work provides an initial framework for future studies to determine the way that higher-order input regulates rhythmic motor patterns.