CCK receptor polymorphisms: an illustration of emerging themes in pharmacogenomics.
CCK receptor polymorphisms: an illustration of emerging themes in pharmacogenomics.
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DOI：
10.1016/s0165-6147(00)01526-1
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发表时间：
2000-09
影响因子：
13.8
通讯作者：
A. Kopin;E. McBride;K. Schaffer;M. Beinborn
中科院分区：
文献类型：
--
作者：
A. Kopin;E. McBride;K. Schaffer;M. Beinborn
Polymorphisms in G-protein-coupled receptors can alter drug affinity and/or activity. In addition, genetic differences in amino acid sequences can induce ligand-independent signaling, which in turn can lead to disease. With growing efforts in the field of pharmacogenomics, it is anticipated that polymorphism-induced alterations in drug and/or receptor function will be a focus of increasing concern during the course of future drug-development efforts. In this review, the spectrum of pharmacological consequences that result from polymorphisms in the cholecystokinin CCK2receptor will be discussed, thereby illustrating emerging themes in pharmacogenomics.
